Fig. 6.

Previously found cross-links mapped onto model. Domains colored as previously described. Cross-links are shown as blue dashed lines. Residues contributing to cross-links within the PAS/H-NOX cluster are shown in magenta. Residues contributing to cross-links between the PAS/H-NOX cluster and the coiled coil are shown in green. The conformational space sampled by sGC in our reconstructions allows rationalizing a large amount of available cross-linking data when taking into account the fact that not all cross-links with the helical domains occur simultaneously.