Table 1.

Main demographic, clinical and echocardiographic findings of preterm neonates before treatment with paracetamol

Characteristics at baseline
Demographic and clinical features
N.	8
Body weight at birth, g	724 ± 173
Gestational age at birth, weeks	26 ± 2
Caesarian section, n (%)	6 (75.0)
Male, n (%)	6 (75.0)
Apgar at 5 minutes	5 ± 1
Resuscitation at birth, n (%)	8 (100)
Body weight at enrollment, g	743.7 ± 167.6
Age at enrollment, h	66 ± 28
Contraindication to COX-inhibitors
Oliguria, n (%)	4 (50.0)
Thrombocytopenia, n (%)	2 (25.0)
Intraventricular hemorrhage, n (%)	1 (12.5)
Blood in gastric aspirates, n (%)	1 (12.5)
Hyperbilirubinemia requiring phototherapy, n (%)	4 (50.0)
Hyperbilirubinemia requiring exchange transfusion, n (%)	0 (0.0)
Echocardiographic findings
Diameter of the ductus ≥ 1.5 mm, n (%)	3 (37.5)
Left-atrium-to-aortic-root ratio > 1.6, n (%)	6 (75.0)
Unrestrictive pulsatile transductal flow, n (%)	1 (12.5)
Reverse flow in the descending aorta, n (%)	2 (25.0)

Notes. Data are expressed as mean ± standard deviation, when not specified.