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. Author manuscript; available in PMC: 2014 Mar 3.
Published in final edited form as: Cell Stem Cell. 2012 Jun 14;10(6):685–689. doi: 10.1016/j.stem.2012.04.006

Figure 1. Lineage Tracing in Adult Tissue Stem Cell Systems.

Figure 1

(A) A self-renewing stem cell is labeled with a specific marker (green). All cells in the hierarchy are permanently marked in long-term follow up.

(B) Specific labeling of mature, differentiated cells. If these cells are replaced by a mature stem/progenitor, the label will disappear from the mature population with time.

(C) A progenitor, not capable of indefinite self-renewal, is labeled. After short follow-up, multiple lineages are marked. However, the marked cells disappear after longer times.