Fig. 1.

Schematic representation of an aminoacyl-tRNA synthetase. Various aaRS domains are illustrated: the editing domain (red); catalytic domain (cyan); anticodon-binding domain (indigo); and parasite-specific domains (purple). Possible sites of interaction between aaRS and compound (with existing examples) are indicated by numbers: editing site (1); active site (2); allosteric sites (3); parasite-specific domains (4); and anticodon-binding site (5). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)