Table 6.
Pregnancy and HEV: Vertical transmission.
| Author, year and country | No of HEV +ve pregnant women | No of fetus HEV +ve | Maternal complications and deaths | Fetal complications | Fetal follow up |
|---|---|---|---|---|---|
| Kumar,84 2004, UAE | 28 2 died undelivered 22 AVH 4 ALF | 26/26 (100%) HEV RNA +ve | 2 died undelivered 1 ALF died | 10 babies: 8 term, 2 premature between 34 and 36 weeks 5 neonates had elevated ALT Deaths: 2 1 each had hypothermia and hypoglycemia | All surviving infants were negative by 9 months of age. Mother to infant transmission 100% |
| Khuroo,85 2003, Kashmir, India |
26 5 died undelivered 11 AVH 15 ALF | 15/19 (79%) | 5 died undelivered 9/15 (60%) ALF died Total delivery (21) Abortions 2 Premature 4 Full term 15 |
Icteric hepatitis: 7 Anicteric hepatitis: 5 Elevated bilirubin, normal AST/ALT: 3 Deaths: 7/19 (37%) Prematurity: 1 Icteric HEV: 3 Anicteric HEV: 2 Hyperbilirubinemia: 1 | All surviving babies HEV RNA negative by 32 weeks |
| Singh,83 2003, New Delhi, India | 22 8 AVH 14 ALF | 3/6 (50%) | 14/22 (63.6%) died All ALF died |
– | – |
| Kumar,86 2004, New Delhi, India | 28 19 AVH 9 ALF | 6/18 (33%) | 7/26 died (All ALF) 5/26 died undelivered |
Prematurity: 66% | – |
| Patra,45 2007, New Delhi, India | 132 59 AVH 73 ALF | – | 54/132 (41%) | Preterm delivery (90%) Abortions (8%) Still birth (54%) |
AVH: acute viral hepatitis, ALF: acute liver failure.