Table 2.
Associations between CYP2B6 single nucleotide polymorphisms (SNP) and with virologic response1 to NNRTI-based regimens in women who were naïve to antiretroviral drugs (N=91).
| Crude | Adjusted for SR Race/Ethnicity3 | Adjusted for top three PCs4 | |
|---|---|---|---|
| CYP2B6 SNP2 | OR (95% CI) | OR (95% CI) | OR (95% CI) |
| rs34097093 | |||
| per C allele | 0.70 (0.25-1.99) | 1.21 (0.39-3.77) | 1.25 (0.37-4.22) |
| p trend | 0.50 | 0.74 | 0.72 |
| rs1042389 | |||
| per C allele | 0.88 (0.38-2.03) | 1.14 (0.46-2.84) | 1.13 (0.43-2.94) |
| p trend | 0.76 | 0.77 | 0.80 |
| rs81927095 | |||
| CC | 1.00 | 1.00 | 1.00 |
| CT | 1.87 (0.21-16.52) | 3.35 (0.38-29.90) | 2.96 (0.30-28.87) |
| rs3745274 | |||
| per T allele | 2.42 (0.93-6.30) | 2.49 (0.90-6.88) | 3.61 (1.16-11.22) |
| p trend | 0.07 | 0.08 | 0.03 |
| rs28399499 | |||
| per C allele | 1.32 (0.30-5.91) | 2.23 (0.47-10.61) | 3.63 (0.69-19.18) |
| p trend | 0.71 | 0.31 | 0.13 |
1
Virologic response was defined as achievement of undetectable viral load up to 54 weeks after self-reported initiation of NNRTI-based regimen
2
rs3211371 could not be analyzed due to lack of non-responders with the TC genotype
3
Adjusted for self-reported (SR) race/ethnicity (White, Hispanic, African American, Asian/Native American/Other)
4
Adjusted for the top three genetic ancestry principal components (PCs)
5
No carriers of the TT genotype observed