Table 2.
Selected candidate genes expected to explain variation in cortisol secretion
| Gene Symbola | no. of SNPs (Illumina550k) |
Position |
|---|---|---|
| Corticosteroid biosynthesis | ||
|
| ||
| CYP21A2 | 35 | 6:32014061-32217398 |
| CYP11B1 | 35 | 8:143850775-144058238 |
| CYP17A1 | 35 | 10:104480278-104687280 |
| HSD3B2 | 39 | 1:119659296-119867174 |
| CYP11A1 | 48 | 15:72317156-72547134 |
| MC2R | 48 | 18:13774624-13975517 |
| STAR | 7 | 8:38019375-38227757 |
| PRKAR1A | 41 | 17:63923130-64159026 |
|
| ||
| Central HPA-axis control & negative feedback | ||
|
| ||
| NR3C1 | 58 | 5:142537689-142863447 |
| NR3C2 | 104 | 4:149120957-149677462 |
| AVP | 45 | 20:2911203-3113370 |
| AVPR1A | 44 | 12:61726483-61932857 |
| CRH | 24 | 8:67,251,173- 67,253,252 |
| CRHR1 | 47 | 17:41117449-41368973 |
| CRHR2 | 53 | 7:30559388-30788665 |
| POMC | 34 | 2:25137226-25345063 |
| MC4R | 48 | 18:56089544-56290981 |
| POU1F1 | 42 | 3:87291473-87508427 |
| PROP1 | 26 | 5:177251842-177455849 |
| TBX19 | 49 | 1:166416902-166650288 |
| LEPR | 82 | 1:65558906-65975410 |
| LEP | 37 | 7:127568567-127784918 |
| FKBP5 | 48 | 6:35549346-35864692 |
|
| ||
| Cortisol inactivation and metabolism | ||
|
| ||
| HSD11B2 | 8 | 16:65922537-66128955 |
| HSD11B1 | 58 | 1:207826173-208074918 |
| DHRS9 | 32 | 2:169534209-169746650 |
| SRD5A1 | 78 | 5:6586500-6822675 |
| SRD5A2 | 20 | 2:31503160-31759544 |
| AKR1D1 | 56 | 7:137327054-137553590 |
| CYP3A4 | 20 | 7:99092540-99319744 |
| H6PD | 55 | 1:9117450-9353981 |
| SERPINA6 | 73 | 14:93740338-93959441 |
| ACE | 26 | 17:58808166-59048711 |
|
| ||
| 33 genes | 1456 SNPs | |
Abbeviations: SNP, single nucleotide polymorphism
a
full gene names are given in supplementary material (SM) table 1