Table 4.
Main findings GWAS cortisolAUC and replication results
| SNP | Gene | Chr. | Variant | Rotterdam Study | Whitehall II Study | meta-analysis | |||
|---|---|---|---|---|---|---|---|---|---|
| (n=1711) | (n=2836) | (n=4547) | |||||||
|
| |||||||||
| beta | p-value | beta | p-value | beta | p-value | ||||
| cortisolAUC (nmol/L) | |||||||||
| rs8026512 | - | 15 | T > C | −0.57 | 6.04e-06 | 0.13 | 0.037 | −0.01 | 0.830 |
| rs2252459 | ALCAM | 3 | T > C | 0.53 | 8.75e-06 | −0.13 | 0.039 | 0.01 | 0.803 |
| rs9470080 | FKBP5 | 6 | G > A | −0.55 | 1.26e-05 | −0.025 | 0.702 | −0.14 | 0.017 |
| rs9394309 | FKBP5 | 6 | A > G | −0.56 | 1.58e-05 | −0.006 | 0.927 | −0.12 | 0.037 |
Abbreviations: SNP, single nucleotide polymorphism; Chr., Chromosome