Table 1.

Studies that have demonstrated association of specific genotypes with anti-TB DILI.

Drug	Genotype	Hazard ratio	Cases (n)	p Value
Isoniazid36	NAT2*6/6 or NAT2*6/7	3.7	33	0.003
Isoniazid38,39	CYP2E1 c1/c1	2.5	49	0.009
	CYP2E1 C/D or C/C	3.2	41	0.005
Anti-TB drugs and HAART52	NAT2*4, *12 or *13	0.4	65	0.04
	ABCB1 3435T/T	5.3	65	0.02
Isoniazid92	MnSOD T/C or C/C	2.5	63	0.02
Isoniazid40,41,92	GSTM1 null92	2.2	63	0.03
	GSTM1 null40	2.1	66	<0.05
	GSTT1 null41	2.6	95	0.03
Anti-TB drugs90	BACH1 C/C at rs2070401 MAFK G/A or A/A at rs4720833	9.7a	100	0.0006
Anti-TB drugs81	HLA-DQB1*0201	1.9	56	0.01
	HLA-DQA1*0102	0.2	56	<0.001

BACH1 gene encodes transcription regulator protein BACH1 (BTB and CNC homology 1).

MAFK gene encodes small Maf basic leucine zipper protein MafK.

^aHazard ratio for the any of the two single-nucleotide polymorphism (SNPs).