Table 1.
Enriched pathways in blood and brain of Fmr1 knockout mice
| KEGG categories | Name | SIZE | NES | NOM p-val | FDR q-val |
|---|---|---|---|---|---|
|
Brain
|
|
|
|
|
|
| Nervous system |
HSA04080 Neuroactive ligand receptor interaction |
223 |
2.34 |
< 0.0005 |
0.0000 |
| |
HSA04720 Long-term potentiation |
62 |
−2.15 |
< 0.0005 |
0.0023 |
| |
HSA04540 Gap junction |
77 |
−1.75 |
< 0.0005 |
0.0429 |
| |
HSA04360 Axon guidance |
125 |
−1.81 |
< 0.0005 |
0.0480 |
| Immune system |
HSA04060 Cytokine-cytokine receptor interaction |
212 |
2.72 |
< 0.0005 |
< 0.0005 |
| |
HSA04610 Complement and coagulation cascades |
47 |
2.32 |
< 0.0005 |
< 0.0005 |
| |
HSA04650 Natural killer cell mediated cytotoxicity |
95 |
1.70 |
0.0015 |
0.0379 |
| |
HSA04612 Antigen processing and representation |
42 |
1.67 |
0.0049 |
0.0397 |
| |
HSA04640 Hematopoietic cell lineage |
66 |
2.09 |
< 0.0005 |
0.0004 |
| Signaling pathways |
HSA01430 Cell communication |
118 |
2.14 |
< 0.0005 |
0.0004 |
| |
HSA04630 Jak-STAT signaling pathway |
137 |
2.07 |
< 0.0005 |
0.0005 |
| |
HSA04070 Phosphatidylinositol signaling system |
65 |
1.77 |
0.0029 |
0.0420 |
| |
HSA04910 Insulin signaling pathway |
126 |
1.80 |
< 0.0005 |
0.0455 |
| Metabolism |
HSA00150 Androgen and estrogen metabolism |
33 |
1.84 |
0.0043 |
0.0118 |
| |
HSA00590 Arachidonic acid metabolism |
39 |
1.81 |
0.0017 |
0.0147 |
| |
HSA00361 γ-hexachlorocyclohexane degradation |
17 |
1.69 |
0.0118 |
0.0370 |
| |
HSA00020 Citrate cycle |
25 |
1.93 |
0.0023 |
0.0375 |
| |
HSA00592 α-linolenic acid metabolism |
15 |
1.70 |
0.0127 |
0.0392 |
| |
HSA00251 Glutamate metabolism |
30 |
1.87 |
0.0038 |
0.0430 |
| Folding, sorting, and degradation |
HSA04120 Ubiquitin mediated proteolysis |
36 |
1.78 |
0.0039 |
0.0453 |
| |
HSA04130 Snare interactions in vesicular transport |
29 |
1.84 |
< 0.0005 |
0.0450 |
|
Blood
|
|
|
|
|
|
| Signaling pathways | HSA04070 Phosphatidylinositol signaling system | 65 | 1.78 | < 0.0005 | 0.0500 |