Table 2.
Enriched pathways in blood and brain of Tsc2+/− mice
| KEGG categories | Name | SIZE | NES | NOM p-val | FDR q-val |
|---|---|---|---|---|---|
|
Brain
|
|
|
|
|
|
| Immune system |
HSA04060 Cytokine-cytokine receptor interaction |
212 |
2.37 |
< 0.0005 |
< 0.0005 |
| |
HSA04640 Hematopoietic cell lineage |
66 |
1.75 |
< 0.0005 |
0.0389 |
| Signaling pathways |
HSA04010 MAPK signaling pathway |
241 |
−1.92 |
< 0.0005 |
0.0431 |
| |
HSA01430 Cell communication |
118 |
2.15 |
< 0.0005 |
0.0007 |
| Translation |
HSA03010 Ribosome |
66 |
3.21 |
< 0.0005 |
< 0.0005 |
| Metabolism |
HSA00563 Glycosylphosphatidylinositol anchor biosynthesis |
21 |
−1.85 |
0.0017 |
0.0444 |
| |
HSA00190 Oxidative phosphorylation |
110 |
2.75 |
< 0.0005 |
< 0.0005 |
| |
HSA00980 Metabolism of xenobiotics by cytochrome P450 |
35 |
1.77 |
< 0.0005 |
0.0379 |
|
Blood
|
|
|
|
|
|
| Nervous system |
HSA05010 Alzheimer’s disease |
26 |
1.92 |
< 0.0005 |
0.0034 |
| Immune system |
HSA04620 Toll-like receptor signaling pathway |
94 |
2.00 |
< 0.0005 |
0.0016 |
| |
HSA04662 B cell receptor signaling pathway |
60 |
1.85 |
< 0.0005 |
0.0072 |
| Cell growth and death |
HSA04110 Cell cycle |
107 |
−2.31 |
< 0.0005 |
0.0005 |
| |
HSA04210 Apoptosis |
73 |
1.78 |
0.0006 |
0.0181 |
| Translation |
HSA03010 Ribosome |
66 |
1.68 |
0.0026 |
0.0468 |
| Metabolism |
HSA01032 Glycan structures degradation |
29 |
2.16 |
< 0.0005 |
0.0000 |
| |
HSA00530 Aminosugars metabolism |
29 |
1.95 |
0.0007 |
0.0035 |
| |
HSA00531 Glycosaminoglycan degradation |
17 |
1.92 |
< 0.0005 |
0.0043 |
| |
HSA00511 Other glycan degradation |
15 |
1.88 |
0.0007 |
0.0047 |
| HSA00600 Sphingolipid metabolism | 31 | 1.69 | 0.0064 | 0.0473 |