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. 2014 Feb 14;11:30. doi: 10.1186/1743-422X-11-30

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Copyright © 2014 Tian et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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CRTC2 enhances HBV replication by inducing PGC1α expression. (A) PGC1α expression level in Huh-7 cells transfected with p-CRTC2 with or without FSK treatment. (B) HBV transcript amounts in Huh-7 cells transfected with 1.3× wtHBV plasmid and p-PGC1α. (C) Effect of PGC1α knock down on luciferase activity in Huh-7 cells transfected with pGL-3-ENII-luc and p-CRTC2 with FSK treatment. (D-F) Effect of PGC1α knock down on HBV mRNA level (D), HBV core protein expression (E), and HBV DNA replication intermediates (F) in Huh-7 cells transfected with 1.3× wtHBV plasmid and p-CRTC2 with FSK treatment. *p < 0.05; **p < 0.01.