Table 3.
Univariate and multivariablea analyses to identify factors associated with severe hepatitis.
| Variables | Severe hepatitis (n = 14) | Uncomplicated hepatitis (n = 81) | P-value |
|---|---|---|---|
| Age (yrs): mean ± SD | 37.57 ± 15.38 | 31.96 ± 12.53 | 0.138 |
| BMI (kg/m2): mean ± SD | 21.82 ± 2.59 | 22.18 ± 3.38 | 0.735 |
| Male sex: no. (%) | 10 (71.43) | 60 (74.07) | 1.000 |
| Abnormal waist–hip ratio: no.(%) | 2 (20.00) | 13 (30.23) | 0.706 |
| Metabolic syndrome: no. (%) | 1 (11.11) | 10 (13.70) | 1.000 |
| Diabetes: no. (%) | 5 (35.71) | 7 (8.64) | 0.015 |
| NAFLD: no. (%) | 1 (7.14) | 4 (5.0) | 0.542 |
| HBV: no. (%) | 9 (64.28) | 19 (23.46) | 0.004 |
| HAV: no. (%) | 1 (7.14) | 11 (13.58) | 0.687 |
| HEV: no. (%) | 4 (28.57) | 51 (62.96) | 0.021 |
BMI: body mass index; NAFLD: non-alcoholic fatty liver disease; HBV: hepatitis B virus; HAV: hepatitis A virus; HEV: hepatitis E virus.
a
Multiple variable logistic regression analysis revealed presence of diabetes mellitus and acute hepatitis B infection were the only independent variable associated with severe hepatitis. Presence of diabetes mellitus had an OR of 4.022 (95% CI: 0.96–16.83), P = 0.057 and acute hepatitis B had an OR of 4.702 (CI: 1.34–16.47), P = 0.015.