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. 2014 Feb 13;7:21. doi: 10.1186/1757-2215-7-21

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Copyright © 2014 Ortega et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Effect of simvastatin (1 μM) and resveratrol (3-10 μM) on mRNA expression of Star (A), Cyp11a1 (B), Hsd3b1 (C) and Cyp17a1 (D). Theca-interstitial cells were cultured in chemically defined media supplemented with LH (5 ng/ml) for 48 h in the absence (control) or in the presence of simvastatin and/or resveratrol. Total RNA was isolated, and mRNA expression was determined using quantitative real-time PCR reactions and normalized to Hprt mRNA levels. Results are presented as a percentage of control. Each bar represents mean ± SEM from three independent experiments (each with N = 4). Means with no superscripts in common are significantly different (P <0.05).