Table 1.
Registries of drug-induced liver injury.
| Country | Spain18 | Sweden20 | USA19 | Japan21 | India9,a |
|---|---|---|---|---|---|
| Year | 1994–2004 | 1970–2004 | 2004–2007 | 1997–2006 | 1997–2008 |
| No. of cases | 461 | 784 | 300 | 1676 | 313 |
| Mean age (years) | 53 | 58 | 48 | 55 | 39.3 |
| Females (%) | 49 | 58 | 48 | 56.3 | 42 |
| % with jaundice | 71 | 73 | 65.5 | ||
| % hospitalized | 53 | 54 | 78 | ||
| % dead/transplanted | 7 | 9.2 | 9 | 3.75 | 17.3 |
| Injury pattern: Hepatocellular Mixed Cholestasis |
55.9 19.3 21.4 |
52.2 26.2 21.6 |
59 20 21 |
NA | |
| Implicated drugs | Antibiotics (32%) CNS agents (17%) Musculoskeletal agents (17%) GI drugs (10%) Anti-TB drugs (7.2%) |
Antibiotics (27%) NSAID (4.8%) |
Antibiotics (45%) CNS agents (15%) Immunomodulators (5%) Analgesics (5%) |
Antibiotics (14.3%) CNS agents (10.1%) Dietary supplements (10%) Anti-inflammatory drugs (9.9%) Circulatory/respiratory system (7.5%) Herbal drugs (7.1%) |
Anti-TB drugs (58%) Antiepileptic drugs (11%) CNS agents (5.4%) Dapsone (5.4%) |
a
Single center.