Table 3.

Types of idiosyncratic drug-induced liver injury (Adapted from Ref. ²⁹).

Basis for injury	Latency period	Dose related	Skin rashes, fever, LNE, eosinophilia	Rechallenge	Drugs
Hypersensitivity	1–6 weeks	No	Yes	No	Phenytoin Carbamazepine Lamotrigine
Metabolic	1–52 weeks, variable	Yes	No	Yes	INH, PZA

Abbreviations: LNE: lymph node enlargement, INH: isoniazid, PZA: pyrazinamide.