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Mechanism of drug-induced liver injury (Adapted from Ref. 29).
| Mechanism of injury | Experimental reproducibility | Dose related | Human incidence | Latency period | Drugs |
|---|---|---|---|---|---|
| Intrinsic hepatotoxicity | Yes | Yes | High | Usually short (days) | Paracetamol, Phosphorus |
| Idiosyncratic hepatotoxicity | Lackinga | Usually no | Low | Few days–months | INH, RIF, PZA, Cotrimoxazole, Phenytoin |
Few animal models for metabolic idiosyncrasy but not immunoallergic idiosyncrasy.
