Table 4.
Hazard ratios at 15 years of breast cancer-specific mortality, all subjects
| Variables | Univariate
|
Multivariateb
|
||
|---|---|---|---|---|
| HR (95 % CI) | p value | HR (95 % CI) | p value | |
| Birth after diagnosis | ||||
| No | 1 | 1 | ||
| Yes | 0.91 (0.38–2.18) | 0.83 | 0.76 (0.31–1.91) | 0.56 |
| Birth after diagnosis | ||||
| No pregnancy | 1 | 1 | ||
| Pregnancy associated | 0.89 (0.30–2.65) | 0.84 | 0.79 (0.25–2.44) | 0.68 |
| Pregnancy following | 0.93 (0.27–3.17) | 0.91 | 0.73 (0.21–2.68) | 0.64 |
| Age at diagnosis (trend per year) | 0.91 (0.82–1.01) | 0.08 | 0.92 (0.82–1.04) | 0.18 |
| Chemotherapy | ||||
| No | 1 | 1 | ||
| Yes | 0.53 (0.22–1.29) | 0.16 | 0.39 (0.14–1.09) | 0.07 |
| Bilateral salpingo-oophorectomya | ||||
| No | 1 | 1 | ||
| Yes | 0.19 (0.06–0.57) | 0.003 | 0.20 (0.06–0.62) | 0.006 |
| Tumor size | ||||
| < 2 cm | 1 | 1 | ||
| 2–5 cm | 1.78 (0.51–6.33) | 0.37 | 2.08 (0.55–7.96) | 0.28 |
| > 5 cm | 5.70 (1.03–31.4) | 0.05 | 8.980 (1.32–61.6) | 0.02 |
| Lymph nodes | ||||
| Negative | 1 | 1 | ||
| Positive | 1.67 (0.51–5.48) | 0.40 | 1.79 (0.50–6.44) | 0.37 |
| Receptor status | ||||
| ER− | 1 | 1 | ||
| ER+ | 0.42 (0.05–3.39) | 0.41 | 0.39 (0.04–3.63) | 0.41 |
HR hazard ratio, CI confidence interval
a
Oophorectomy is time dependent
b
All variables used in the regression