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. Author manuscript; available in PMC: 2014 Mar 3.
Published in final edited form as: Cancer Res. 2012 Oct 16;72(24):6435–6446. doi: 10.1158/0008-5472.CAN-12-2181

Figure 6. Depletion of Src kinase by siRNA mimics miR-23b over-expression.

Figure 6

A) Src protein levels were significantly attenuated with 50nM Src-siRNA duplex (Si) compared to a nonsilencing siRNA duplex (Con), (P-PC3, D-Du145). B–C) Cell cycle analysis showing an increase in the G0/G1 phase of PC3 and DU145 cells transfected with siRNA. D–E) Apoptosis assay showing induction of apoptosis after Src knockdown by siRNA in PC3 and Du145 cells. *p<0.05. F) Western blot analysis showing the protein expressions of Src and its downstream genes are rescued by antimiR-23b transfection.

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