Table 3.
Distribution of MSH3 and MSH6 gene polymorphisms in PC patients and controls
| Gene | Genotype | Cases (n=110) (%) | Controls (n=110) (%) | Age adjusted OR | 95%CI | P-value |
|---|---|---|---|---|---|---|
| MSH3 | ||||||
| exon4 (G/A) | G/G | 21 (19) | 34 (31) | |||
| G/A | 78 (72) | 69 (63) | ||||
| A/A | 11 (10) | 7 (6) | 1.63 | 0.61–4.39 | 0.44 | |
| G/A + A/A | 89 (81) | 76 (69) | 1.87 | 1.00–3.50 | 0.04 | |
| G allele | 120 (55 %) | 137 (62 %) | ||||
| A allele | 100 (45 %) | 83 (38 %) | 1.33 | 0.76–2.34 | ||
| MSH3 | ||||||
| exon23 (A/G) | A/A | 60 (55) | 72 (65) | |||
| A/G | 43 (39) | 31 (28) | ||||
| G/G | 7 (6) | 7 (6) | 1.00 | 0.34–2.95 | ||
| A/G + G/G | 50 (45) | 38 (34) | 1.57 | 0.92–2.72 | 0.09 | |
| A allele | 163 (74 %) | 175 (80 %) | ||||
| G allele | 57 (26 %) | 45 (20 %) | 1.34 | 0.86–2.10 | ||
| MSH6 | ||||||
| exon1 (G/A) | G/G | 44 (40) | 46 (42) | |||
| G/A | 55 (50) | 54 (49) | ||||
| A/A | 11 (10) | 10 (9) | 1.11 | 0.45–2.73 | 0.82 | |
| G/A + A/A | 66 (60) | 64 (58) | 1.10 | 0.63–1.85 | 0.78 | |
| G allele | 143 (65 %) | 146 (66 %) | ||||
| A allele | 77 (35 %) | 74 (34 %) | 1.06 | 0.72–1.57 | ||
| MSH6 | ||||||
| Intron 2 (C/T) | C/C | 16 (15) | 20 (18) | |||
| C/T | 69 (62) | 59 (54) | ||||
| T/T | 25 (23) | 31 (28) | 0.75 | 0.41–1.38 | 0.35 | |
| T/T + C/T | 94 (85) | 90 (82) | 1.31 | 0.64–2.67 | 0.46 | |
| C allele | 101 (46 %) | 99 (45 %) | ||||
| T allele | 119 (54 %) | 121 (55 %) | 0.96 | 0.66–1.40 | ||