Table 6.

Comparison between gene genotypes and clinical parameters

		gender			Grade			Stage			pN			pM
Gene (SNP ID)	Genotype	female	male	p value	1+2	3+4	p value	pT1+pT2	pT3+pT4	p value	(−)	(+)	p value	(−)	(+)	p value
		n=65	n=145		n=185	n=25		n=159	n=51		n=200	n=10		n=191	n=19
DKK2 (rs17037102)	GG	35	70	reference	92	13	reference	79	26	reference	99	6	reference	94	11	reference
	GA	24	68	0.27	82	10	0.74	70	22	0.89	89	3	0.41	85	7	0.49
	AA	6	7	0.36	11	2	0.76	10	3	0.89	12	1	0.78	12	1	0.75
	GA+AA	30	75	0.45	93	12	0.83	80	25	0.87	101	4	0.52	97	8	0.47
DKK2 (rs419558)	CC	39	80	reference	107	12	reference	91	28	reference	118	1	reference	113	6	reference
	CT	17	46	0.42	56	7	0.83	48	15	0.96	57	6	0.004	54	9	0.03
	TT	9	19	0.94	22	6	0.11	20	8	0.58	25	3	0.004	24	4	0.08
	CT+TT	26	65	0.51	78	13	0.35	68	23	0.77	82	9	0.002	78	13	0.02
DKK2 (rs447372)	GG	39	78	reference	105	12	reference	90	27	reference	116	1	reference	111	6	reference
	GA	17	48	0.31	58	7	0.91	49	16	0.82	59	6	0.005	56	9	0.04
	AA	9	19	0.91	22	6	0.11	20	8	0.54	25	3	0.004	24	4	0.09
	GA+AA	26	67	0.41	80	13	0.41	69	24	0.65	84	9	0.003	80	13	0.03
DKK3 (rs3206824)	GG	50	100	reference	136	14	reference	116	34	reference	143	7	reference	138	12	reference
	GA	13	40	0.23	43	10	0.06	37	16	0.28	50	3	0.77	46	7	0.26
	AA	2	5	0.79	6	1	0.66	6	1	0.61	7	0		7	0
	GA+AA	15	45	0.24	49	11	0.07	43	17	0.39	57	3	0.92	53	7	0.41
DKK3 (rs11022095)	GG	11	17	reference	25	3	reference	21	7	reference	27	1	reference	23	5	reference
	GA	28	60	0.47	76	12	0.68	67	21	0.91	83	5	0.61	80	8	0.21
	AA	26	68	0.24	84	10	0.99	71	23	0.95	90	4	0.87	88	6	0.06
	GA+AA	54	128	0.31	160	22	0.83	138	44	0.93	173	9	0.75	168	14	0.08
DKK3 (rs1472189)	CC	47	108	reference	138	17	reference	119	36	reference	150	5	reference	146	9	reference
	CT	16	35	0.89	46	5	0.82	38	13	0.74	46	5	0.05	41	10	0.003
	TT	2	2	0.41	1	3	0.0001	2	2	0.21	4	0		4	0
	CT+TT	18	37	0.74	47	8	0.48	40	15	0.55	50	5	0.07	45	10	0.005
DKK3 (rs7396187)	GG	46	92	reference	127	11	reference	108	30	reference	132	6	reference	127	11	reference
	GC	16	42	0.43	46	12	0.01	40	18	0.11	54	4	0.46	51	7	0.36
	CC	3	11	0.36	12	2	0.42	11	3	0.92	14	0		13	1	0.92
	GC+CC	19	53	0.31	58	14	0.014	51	21	0.14	68	4	0.69	64	8	0.45
DKK3 (rs2291599)	CC	34	67	reference	93	8	reference	76	25	reference	95	6	reference	90	11	reference
	CT	26	55	0.82	70	11	0.21	62	19	0.84	77	4	0.77	74	7	0.61
	TT	5	23	0.11	22	6	0.04	21	7	0.98	28	0		27	1	0.24
	CT+TT	31	78	0.41	92	17	0.08	83	26	0.88	105	4	0.44	101	8	0.37
DKK4 (rs2073664)	CC	40	104	reference	127	17	reference	107	37	reference	137	7	reference	129	15	reference
	CT	18	22	0.03	35	5	0.91	30	10	0.92	37	3	0.52	36	4	0.94
	TT	7	19	0.93	23	3	0.96	22	4	0.26	26	0		26	0
	CT+TT	25	41	0.14	58	8	0.95	52	14	0.48	63	3	0.92	62	4	0.31
sFRP4 (rs1802073)	CC	15	36	reference	42	9	reference	37	14	reference	47	4	reference	43	7	reference
	CA	25	57	0.89	70	12	0.64	65	17	0.37	79	3	0.29	76	6	0.21
	AA	25	52	0.71	73	4	0.02	57	20	0.85	74	3	0.34	71	6	0.26
	CA+AA	50	109	0.78	143	16	0.15	122	37	0.54	153	6	0.24	147	12	0.17
sFRP4 (rs1802074)	AA	15	21	reference	32	4	reference	28	8	reference	35	1	reference	35	1	reference
	AG	15	54	0.03	65	4	0.33	53	16	0.92	67	2	0.97	64	5	0.35
	GG	35	70	0.36	88	17	0.09	78	27	0.68	98	7	0.38	92	13	0.09
	AG+GG	50	124	0.13	153	21	0.87	131	43	0.75	165	9	0.54	156	18	0.15
SMAD7 (rs12953717)	CC	46	79	reference	108	17	reference	94	31	reference	119	6	reference	111	14	reference
	CT	13	55	0.01	61	7	0.51	51	17	0.98	65	3	0.91	65	3	0.11
	TT	6	11	0.91	16	1	0.37	14	3	0.52	16	1	0.85	15	2	0.95
	CT+TT	19	66	0.03	77	8	0.36	65	20	0.83	81	4	0.97	80	5	0.19
DAAM2 (rs6937133)	GG	12	18	reference	26	4	reference	22	8	reference	29	1	reference	26	4	reference
	GA	20	45	0.37	59	6	0.54	48	17	0.96	62	3	0.77	56	9	0.95
	AA	33	82	0.23	100	15	0.97	89	26	0.64	109	6	0.67	109	6	0.12
	GA+AA	53	127	0.25	159	21	0.79	137	43	0.74	171	9	0.69	165	15	0.38
DAAM2 (rs2504106)	TT	19	53	reference	64	8	reference	57	15	reference	68	4	reference	66	6	reference
	TC	29	55	0.27	73	11	0.71	62	22	0.43	80	4	0.83	73	11	0.34
	CC	17	37	0.53	48	6	0.99	40	14	0.51	52	2	0.63	52	2	0.29
	TC+CC	46	92	0.31	121	17	0.79	102	36	0.39	132	6	0.69	125	13	0.79

note; Considering multiple comparison,

^ap-value of < 0.05 was regarded as statistically significant