Table 7.
Relationship of Wnt antagonist genes distribution with the expression of beta-catenin
| beta catenin expression (IHC) |
||||
|---|---|---|---|---|
| NO (n=25) | YES (n=31) | p value | ||
| Gene polymorphism | Genotype | n (%) | n (%) | |
| DKK2 (rs17037102) | GG | 18(72) | 21(68) | reference |
| GA | 5(20) | 9(29) | 0.49 | |
| AA | 2(8) | 1(3) | 0.49 | |
| GA+AA | 7(28) | 10(32) | 0.73 | |
| DKK2 (rs419558) | CC | 16(64) | 22(71) | reference |
| CT | 6(24) | 3(10) | 0.18 | |
| TT | 3(12) | 6(19) | 0.63 | |
| CT+TT | 9(36) | 9(29) | 0.58 | |
| DKK2 (rs447372) | GG | 16(64) | 22(71) | reference |
| GA | 7(28) | 3(10) | 0.12 | |
| AA | 2(8) | 6(19) | 0.37 | |
| GA+AA | 9(36) | 9(29) | 0.58 | |
| DKK3 (rs3206824) | GG | 21(84) | 24(77) | reference |
| GA | 4(16) | 6(19) | 0.72 | |
| AA | 0(0) | 1(4) | ||
| GA+AA | 4(16) | 7(23) | 0.54 | |
| DKK3 (rs11022095) | GG | 5(20) | 4(13) | reference |
| GA | 7(35) | 10(32) | 0.48 | |
| AA | 13(45) | 17(55) | 0.52 | |
| GA+AA | 20(80) | 27(87) | 0.47 | |
| DKK3 (rs1472189) | CC | 23(92) | 23(74) | reference |
| CT | 2(8) | 8(26) | 0.08 | |
| TT | 0(0) | 0 | ||
| CT+TT | 2(8) | 8(26) | 0.08 | |
| DKK3 (rs7396187) | GG | 21(84) | 23(74) | reference |
| GC | 4(16) | 5(16) | 0.85 | |
| CC | 0(0) | 3(10) | ||
| GC+CC | 4(16) | 8(26) | 0.38 | |
| DKK3 (rs2291599) | CC | 11(44) | 15(48) | reference |
| CT | 9(36) | 11(35) | 0.86 | |
| TT | 5(20) | 5(16) | 0.67 | |
| CT+TT | 14(56) | 16(52) | 0.74 | |
| DKK4 (rs2073664) | CC | 16(64) | 21(68) | reference |
| CT | 6(24) | 3(10) | 0.21 | |
| TT | 3(12) | 7(22) | 0.45 | |
| CT+TT | 9(36) | 10(32) | 0.77 | |
| sFRP4 (rs1802073) | CC | 6(24) | 10(32) | reference |
| CA | 8(32) | 11(35) | 0.78 | |
| AA | 11(44) | 10(32) | 0.37 | |
| CA+AA | 19(76) | 21(68) | 0.49 | |
| sFRP4 (rs1802074) | AA | 8(32) | 9(29) | reference |
| AG | 12(48) | 11(35) | 0.75 | |
| GG | 5(20) | 11(35) | 0.35 | |
| AG+GG | 17(68) | 22(71) | 0.82 | |