Table 2. Synonymous and nonsynonymous variations of PRRT2 in worldwide populations.
| Ethnic | Nonsynonymous variants | Synonymous variants | pN (nonsynonymous variants/nonsynonymous sites)a | pS (synonymous variants/synonymous sites)a | pN/pS |
| EVS Europe (N = 4300) | 14 | 3 | 0.021 | 0.013 | 1.62 |
| EVS African-American (N = 2012) | 6 | 8 | 0.009 | 0.035 | 0.26 |
| HGDP Asia (N = 439) | 14 | 1 | 0.021 | 0.004 | 4.85 |
| HGDP Africa (N = 108) | 1 | 2 | 0.001 | 0.009 | 0.17 |
| HGDP Europe (N = 159) | 4 | 0 | 0.006 | 0.000 | >1.5b |
a
Number of nonsynonymous and synonymous sites for PRRT2 are 668.5 and 231.5, respectively.
b
For the calculation of the pN/pS for Europe, the value of pS was set to 0.004 (the minimum of 1 synonymous variant observed in 159 individuals).