Table 3.
Tumor characteristics in different etiologies.
| Parameters | All patients (n = 142) | Viral etiology (n = 83) | Alcohol etiology (n = 31) | Cryptogenic etiology (n = 26) | Miscellaneous etiology (n = 2) |
|---|---|---|---|---|---|
| Lesions | |||||
| Single | 51/114 (45%) | 26/66 (39%) | 15/23 (65%) | 10/24 (42%) | – |
| Multi | 63/114 (55%) | 40/66 (61%) | 8/23 (35%) | 14/24 (58%) | 1/1 (100%) |
| Median size of largest lesion, cm | 6.8 (1.0–16.2) | 6.0 (1.0–14.7) | 8.0 (1.5–14.2) | 5.8 (1.5–16.2) | 8.6 (8.6–8.6) |
| Lobes | |||||
| Both | 53/106 (50%) | 36/63 (57%) | 4/19 (21%) | 12/23 (52%) | 1/1 (100%) |
| Right | 38/106 (36%) | 20/63 (32%) | 9/19 (47%) | 9/23 (39%) | 0/1 (0%) |
| Left | 15/106 (14%) | 7/63 (11%) | 6/19 (32%) | 2/23 (9%) | 0/1 (0%) |
| PVT | 55 (39%) | 32 (39%) | 14 (45%) | 8 (31%) | 1 (50%) |
| Median AFP, IU/mL (n = 69)b | 458 (1–73072) | 758 (1–73072) | 235 (3–2708) | 49 (2–13320) | 29635 - |
| Distant metastasis | 25 (18%) | 16 (19%) | 4 (13%) | 4 (15%) | 1 (50%) |
| BCLC stagea | |||||
| A | 17/126 (13%) | 12/73 (16%) | 3/28 (11%) | 2/24 (8%) | 0/1 (0%) |
| B | 29/126 (23%) | 16/73 (22%) | 2/28 (7%) | 11/24 (46%) | 0/1 (0%) |
| C | 44/126 (35%) | 28/73 (38%) | 7/28 (25%) | 8/24 (33%) | 1/1 (100%) |
| D | 36/126 (29%) | 17/73 (23%) | 16/28 (57%) | 3/24 (13%) | 0/1 (0%) |
Abbreviations: PVT, portal vein thrombosis; AFP, alfa-fetoprotein; BCLC, Barcelona Clinic Liver Cancer.
Notes: All values are expressed in median (range) or number (%).
a
P < 0.05 for viral vs alcohol etiology.
b
P < 0.05 for viral vs cryptogenic etiology.