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Synthesis and actions of ET-1 in the thick ascending limb. ET-1 production is stimulated by increased medullary osmolality which occurs during high Na intake. ET-1 can then act in an autocrine manner, via ETB, to stimulate NOS3 activity and inhibit NKCC2. ETB may also increased 20-HETE with possible inhibition of Na/K ATPase activity, although this is unproven. Please see text for definitions of abbreviations.
