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Role of the renal ET system in control of urinary acid excretion. Dietary acid intake stimulates renal and possibly adrenal ET-1 production. Renal ET-1 increases proximal tubule H+ secretion and distal nephron H+ secretion and bicarbonate reabsorption. Adrenal ET-1 increases aldosterone which stimulates distal nephron H+ secretion. Please see text for definitions of abbreviations.
