Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Integrated renal response to high Na intake. High Na intake increases renal ET-1 synthesis, particularly in the nephron. This can reduced tubule Na reabsorption by inhibiting Na transport mechanisms in the proximal tubule, thick ascending limb and collecting duct. ET-1, most likely derived from the medullary collecting duct and/or medullary thick ascending limb, may also increase medullary blood flow through vasodilation of vasa recta.
