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. Author manuscript; available in PMC: 2014 Mar 3.
Published in final edited form as: Lab Invest. 2012 Jan 16;92(4):543–555. doi: 10.1038/labinvest.2011.200

Figure 4. Effect of Gsk3β inhibitor on β-cell function of c-KitWv/+/1-AKP mice.

Figure 4

(a) In vivo glucose-stimulated insulin secretion of c-Kit+/+/saline, c-Kit+/+/1-AKP, c-KitWv/+/saline, and c-KitWv/+/1-AKP groups. c-KitWv/+/1-AKP groups demonstrated an increase in plasma insulin release after glucose loading (n=3–8). (b) Insulin secretion is improved in isolated islets from male c-KitWv/+/1-AKP mice in response to 22mM glucose challenge; data are expressed as fold change normalized to basal (2.2mM glucose) secretion (n=4–5). *P<0.05, **P<0.01, ***P< 0.001 vs. c-KitWv/+/saline group.