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(a,b) Light microscopy micrographs of transversally cut quadriceps muscles of aging euploid (a) and trisomic (b) mice. Bars: 40 μm. (c) Cross-sectional area (mean±SE) of myofibres from 12- and 19 month-old euploid (Eu) and trisomic (Tr) mice. Two-way ANOVA revealed significant effect of the factors “trisomy” (P<0.001), “age” (P<0.001) and their interaction term (P<0.001).
