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Kaplan-Meier estimates of overall survival (OS) by treatment (procarbazine, lomustine, and vincristine [PCV] plus radiotherapy [RT] or RT) for patients with (A) IDH-mutated and (B) nonmutated tumors. Hazard ratio (HR) ratio for OS for those with mutated tumors was 0.59 (95% CI, 0.40 to 0.86; P = .006); HR for those with nonmutated tumors was 1.14 (95% CI, 0.63 to 2.04; P = .67).
