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. 2014 Mar 3;9(3):e89835. doi: 10.1371/journal.pone.0089835

Figure 6. β-catenin/Wnt signaling was activated in the kidneys of Gpr48−/− mice.

Figure 6

(a) The expression of β-catenin was analyzed by Western blot. (b) Western analyses of β-catenin in cytolosic and nuclear fractions in the kidney cells of Gpr48 KO and WT mice. (c)RT-PCR results showed the expressions of different Wnt genes in the kidneys of Gpr48 KO and WT adult mice. (d) The expressions of different Fzd genes were evaluated by RT-PCR in the kidneys of Gpr48 KO and WT adult mice. (e) Western blot analysis shows the dramatic increases of Wnt2b, Wnt4b and Wnt7 in Gpr48 KO mice. All data are expressed as Mean ± SD, n = 15. ***p<0.001, ** p<0.01,*p<0.05, KO vs WT.