Figure 7. Gpr48 deficiency altered the expression of Wnt signal inhibitors and the activity of noncanical Wnt signal pathway.

(a) Western blot analysis shows that p-akt and p-GSK3βwere increased while axin2 was decreased in gpr48 KO mice. (b) Western blot analysis depicts the levels of p-JNK, p-c-jun and p-c-fos in the kidneys of Gpr48 KO and WT adult mice.