Exposure to light is a concern with numerous medications due to the potential for photodegradation or other chemical reactions that affect drug stability. In 2009, Hospital Pharmacy published a list of oral medications that require protection from light.1 This reference does not provide information on injectable drugs and, to our knowledge, there is no comprehensive list of injectable medications that require protection from light published in the United States.2 Therefore, the purpose of this table is to supplement the previously published list of oral medications by identifying injectable drugs that require protection from light.
A list of injectable medications that require light protection was generated utilizing Facts & Comparisons.3 A comprehensive list of monographs that contained the words “protect” and “light” was created in December 2012. Additional searches were performed using similar phrases such as “exposure to light.” For drug classes that appeared to have several medications requiring light protection, monographs for the whole class were checked. A supplementary search was performed in May 2013 to ensure inclusion of new injectable medications approved through April 2013.
The prescribing information (PI) was used as the primary reference for each injectable medication. Additional resources were used to confirm this information.4–7 For medications with numerous manufacturers, multiple PIs were checked for accuracy. When it was found that not all manufacturers specified the need for light protection, this was noted in the additional comments field and only the brand names of products requiring light protection were listed in the table. When information was not available or consistent among these references, additional sources were checked, a literature search was performed, and/or the manufacturer was contacted. These data are noted in the additional comments field and are referenced accordingly. Despite efforts to confirm the information in at least 2 additional sources, some medications have the PI as the only source with instructions for light protection including those approved between December 2012 and April 2013. When stability depends on light protection during storage, reconstitution, dilution, and/ or administration, the reader should consult the references listed in the additional comments field for further details. Additional storage requirements (eg, temperature, humidity) are not included in this table.
Although every effort has been made to ensure the accuracy and completeness of the information presented in this chart, the reader is advised that the authors, Hospital Pharmacy, or Thomas Land Publishers cannot be held responsible for the currency of the information, for any errors or omissions, or for any consequences that may arise. The reader should consult the product prescribing information for the most current information.
| Drug | Storage | Reconstitution | Dilution | Administration | Additional comments |
| Abatacept Orencia |
X | Protect from light by storing in the original package until time of use.7,8 | |||
| Abobotulinumtoxin A Dysport |
X | X | Protect from light.9 Stability of reconstituted solutions is affected by light exposure; refer to prescribing information for details regarding storage after reconstitution. | ||
| Adalimumab Humira |
X | Protect from exposure to light.10 Do not use if left in direct sunlight. Store in original carton until time of administration.5,10 | |||
| Aflibercept Eylea |
X | Protect from light and store in the original carton until time of use.5,11 | |||
| Aldesleukin Proleukin |
X | Protect intact vials from light and store in carton until time of use.6,12 | |||
| Alemtuzumab Campath |
X | X | Protect from light and direct sunlight.7,13 Stability of diluted solutions is affected by light exposure; refer to prescribing information for details regarding storage after dilution.13 | ||
| Alefacept Amevive |
X | Protect from light and retain in drug/diluent pack until time of use.5,14 | |||
| Alfentanil Alfenta |
X | Protect from light.6,7,15 | |||
| Alglucosidase Alfa Lumizyme Myozyme |
X | X | X | Protect from light.16,17 The reconstituted and diluted solution should be protected from light.5,16,17 | |
| Alteplase, Recombinant Activase Cathflo Activase |
X | Protect from excessive exposure to light during extended storage.7,18,19 Activase: Protect from light in cartons.7 Exposure to light does not affect the potency of either reconstituted solutions or dilutions in compatible infusion solutions.6,18 | |||
| Amino Acid Preparations | X | Tertiary sources state that amino acid products should be protected from light until time of use.6,7 Check the individual prescribing information for the specific product for further information. | |||
| Aminophylline | X | Protect from light and keep vials in carton until time of use.6,7,20 | |||
| Aminophylline Dihydrate | X | Protect from light and store in carton until time of use.6,7,21 | |||
| Amiodarone Nexterone |
X | Use carton to protect contents from light until used.7,22 Does not need to be protected from light during administration but exposure to direct sunlight should be avoided.6,22 | |||
| Amphotericin B Desoxycholate | X | X | X | Protect against exposure to light prior to reconstitution.6,7,23 Stability of reconstituted solutions is affected by light exposure; refer to prescribing information and tertiary source for details regarding storage after reconstitution.6,23 Solutions should be protected from light during administration.23 Several reports indicate that for short-term exposure, little difference in potency is observed between light-protected and light-exposed solutions.6 | |
| Amphotericin B Lipid Complex Abelcet |
X | Protect from exposure to light and retain in carton until time of use.6,7,24 | |||
| Anakinra Kineret |
X | Protect from light.6,25 | |||
| Antihemophilic Factor, Recombinant Advate Helixate FS Kogenate FS Recombinate Xyntha |
X | Advate, Helixate FS, Kogenate FS, Recombinate: Protect from extreme exposure to light and store in carton prior to use.26–29 Xyntha: Protect from light during storage.7,30 | |||
| Anti-inhibitor Coagulant Complex Feiba NF |
X | Store in the original package to protect from light.31 | |||
| Antithymocyte Globulin (Rabbit) Thymoglobulin |
X | Protect intact vials from light.6,7,32 | |||
| Argatroban | X | X | Retain in the original carton to protect from light.6,7,33 Prepared solutions should not be exposed to direct sunlight. Stability of diluted solutions is affected by light exposure; refer to prescribing information for details regarding storage after dilution.33 | ||
| Aripiprazole Abilify |
X | Protect from light and store in original container until time of use.5,6,34 | |||
| Articaine and Epinephrine Septocaine |
X | Protect from light.5,35 | |||
| Ascorbic Acid | X | Protect intact containers from light by keeping them in the carton until ready for use.6,36 | |||
| Atropine AtroPen |
X | Protect from light.37 | |||
| Atropine and Pralidoxime DuoDote |
X | Protect from light.38 Each DuoDote is supplied in a pouch that provides protection from light. | |||
| Azathioprine | X | Protect from light and retain in carton until time of use.6,7,39 | |||
| Bacillus Calmette-Guerin (BCG) TICE BCG BCG vaccine |
X | X | Protect from direct sunlight.40,41 Reconstituted product should be protected from exposure to direct sunlight. Stability of reconstituted solutions is affected by light exposure; refer to prescribing information for details regarding storage after reconstitution. | ||
| Belatacept Nulojix |
X | X | Protect from light by storing in the original package until time of use.7,42 Stability of diluted solutions is affected by light exposure; refer to prescribing information for details regarding storage after dilution.42 | ||
| Bendamustine Treanda |
X | X | Retain in original package until time of use to protect from light.7,43 Stability of diluted solutions is affected by light exposure; refer to prescribing information for details regarding storage after dilution.43 | ||
| Betamethasone Acetate and Betamethasone Sodium Phosphate Celestone Soluspan |
X | Protect from light.5,44 | |||
| Bevacizumab Avastin |
X | Protect vials from light by storing in the original carton until time of use.7,45 | |||
| Bicisate Neurolite |
X | Protect vial A from light.5,46 | |||
| Bortezomib Velcade |
X | X | Retain in the original container to protect from light.5,6,47 Stability of reconstituted solutions is affected by light exposure; refer to prescribing information and tertiary source for details regarding storage after reconstitution.6,47 | ||
| Brentuximab Vedotin Adcetris |
X | Store in the original carton to protect from light.7,48 | |||
| Bumetanide | X | Protect from light.6,49 | |||
| Bupivacaine and Epinephrine Marcaine Vivacaine Sensorcaine Sensorcaine MPF |
X | Solutions containing epinephrine should be protected from light.50–53 | |||
| Buprenorphine Buprenex |
X | Should be protected from prolonged exposure to light.6,7,54 | |||
| Butorphanol | X | Protect from light.6,7,55 | |||
| C1 Esterase Inhibitor (Human) Berinert Cinryze |
X | Store the vial in the original carton to protect from light.7,56,57 | |||
| Calcitriol Calcijex |
X | Keep ampules in package until time of use.58 Drug can be stored in a syringe for up to 8 hours prior to administration but must be protected from direct sunlight.6,7,58 | |||
| Canakinumab Ilaris |
X | X | Store in the original carton to protect from light.5,59 Stability of reconstituted solutions is affected by light exposure; refer to prescribing information for details regarding storage after reconstitution.59 | ||
| Carboplatin | X | Protect intact vials from light.6,7,60 | |||
| Carfilzomib Kyprolis |
X | Retain in original package to protect from light.5,61 | |||
| Carmustine BiCNU |
X | X | X | All forms should be protected from light. Stability of reconstituted and diluted solutions is affected by light exposure; refer to prescribing information for details regarding storage after reconstitution and dilution.62 Refer to tertiary source for details regarding light effects.6 | |
| Cefazolin | X | X | The manufacturer and some tertiary sources recommend to protect from light before reconstitution.5,7,63 One tertiary source recommends protection from light for both the powder and its solutions.6 | ||
| Cefepime Maxipime |
X | Protect from light.6,7,64 | |||
| Cefotaxime Claforan |
X | X | Both the dry material and solutions should be protected from excessive light.6,7,65 | ||
| Cefotetan | X | Intact vials should be protected from light.5,6,66 | |||
| Ceftazidime Fortaz Tazicef |
X | Intact vials should be stored in carton and protected from light.6,7,67,68 | |||
| Ceftriaxone Rocephin |
X | Intact vial should be protected from light.6,7,69 After reconstitution, protection from normal light is not necessary.6,69 | |||
| Cefuroxime Zinacef |
X | Intact vials should be protected from light.6,7,70 | |||
| Cephalosporin-Dextrose Dual Chamber Products | X | All available injectable cephalosporin-dextrose dual chamber products have foil on the product designed to protect the powder from light; if the foil is removed before reconstitution/dilution with dextrose, the powder would still need protection from light.71–77 Once diluted, light protection is not necessary. | |||
| Certolizumab Pegol Cimzia |
X | X | Protect solution from light and store in the carton.78 | ||
| Cetrorelix Cetrotide |
X | Keep the packaged tray in the outer carton to protect it from light.5,79 | |||
| Chloroprocaine Nesacaine Nesacaine-MPF |
X | It is recommended that these vials be stored in the original outer containers, protected from direct sunlight.80 | |||
| Chlorpromazine | X | Protect from light.7,81 | |||
| Choriogonadotropin Alfa Ovidrel |
X | Store in original package and protect from light.5,82 | |||
| Ciprofloxacin | X | Protect from light.6,7,83 Refer to tertiary source for details regarding light effects.6 | |||
| Cisatracurium Nimbex |
X | Protect from light.6,7,84 | |||
| Cisplatin | X | X | Protect unopened container from light.6,85 Stability of diluted solutions is affected by light exposure; refer to prescribing information or tertiary source for details regarding storage after dilution. Refer to tertiary sources for details regarding light effects and exposure to ultraviolet light.6,7,85 | ||
| Cladribine Leustatin |
X | When stored properly and protected from light, unopened vials are stable until the expiration date indicated on the package.6,7,86 | |||
| Clevidipine Cleviprex |
X | Protect from light.7 Storage in cartons protects against photodegradation.87 Protection from light during administration is not required. | |||
| Conivaptan Vaprisol |
X | Do not remove container from overwrap until ready for use. The overwrap is a moisture and light barrier.7,88 | |||
| Corticorelin Ovine Triflutate Acthrel |
X | Stable in the lyophilized form when stored properly and protected from light.89 | |||
| Cosyntropin | X | Protect from light.7,90 The manufacturers of products available in powder form provide no recommendations regarding light protection.91–94 | |||
| Cyanocobalamin | X | The vitamin B12 coenzymes are unstable in light and require protection from light.6,95 | |||
| Cyclosporine SandIMMUNE |
X | Protect from light.6,7,96 Light protection is not required for IV admixtures.6 | |||
| Cytarabine | X | Protect from light and retain in carton until time of use.97–99 Not all manufacturers provide recommendations regarding light protection.*98–100 *multiple products from the same manufacturer provide different recommendations regarding light protection. | |||
| Dacarbazine | X | Protect from light.6,101 Refer to tertiary source for details regarding light effects on reconstituted and diluted solutions.6 | |||
| Dactinomycin Cosmegen |
X | Protect from light.6,7,102 | |||
| Dantrolene Dantrium Revonto |
X | X | The contents of the vial must be protected from direct light and used within 6 hours after reconstitution.7,103,104 Protect reconstituted solution from direct light.7 | ||
| Darbepoetin Alfa Aranesp |
X | Protect vials and prefi lled syringes from light during storage.7,105 | |||
| Daunorubicin Liposome DaunoXome |
X | Protect from light.7,106 | |||
| Daunorubicin Cerubidine |
X | X | Protect from light and retain in carton until time of use.6,7,107 Stability of reconstituted solutions is affected by light exposure; refer to tertiary source for details regarding storage after reconstitution.6 | ||
| Denosumab Prolia Xgeva |
X | Protect from direct light and store in original carton.5,108,109 | |||
| Desirudin Iprivask |
X | Protect from light.5,110 | |||
| Dexamethasone Sodium Phosphate | X | Protect from light and store in container until time of use.5,6,111 | |||
| Dexrazoxane Totect |
X | Protect from light and keep vials in carton until ready for use.7,112 The manufacturers of other products provide no recommendations regarding light protection.113–115 | |||
| Diatrizoate Meglumine/Sodium Cystografin MD-76R |
X | Cystografin should be protected from light.116 MD-76R must be protected from strong daylight or direct exposure to the sun.117 | |||
| Iodipamide Meglumine and Diatrizoate Meglumine Sinografin |
X | Protect from light.118 | |||
| Diazepam | X | Protect from light.6,7,119 | |||
| Digoxin Lanoxin |
X | Protect from light.6,7,120 | |||
| Dihydroergotamine D.H.E. 45 |
X | Store in light-resistant containers and protect from light.7,121 | |||
| Dimenhydrinate | X | Protect from light.5,122 | |||
| Diphenhydramine | X | Protect from light and store in light-resistant containers.6,7,123 | |||
| Dipyridamole Persantine |
X | Protect from direct light and keep covered in carton until time of use.7,124 | |||
| Docetaxel Docefrez Taxotere |
X | Retain in the original package to protect from bright light.6,7,125,126 | |||
| Dolasetron Anzemet | X | Protect intact containers from light.6,7,127 Stability of diluted solutions is affected by light exposure; refer to prescribing information for details regarding storage after dilution.127 | |||
| Dopamine | X | Protect from light and retain in carton until time of use.128 Refer to tertiary source for details regarding effects of fluorescent and blue phototherapy light.6 | |||
| Doxercalciferol Hectorol |
X | Protect from light.7,129 | |||
| Doxorubicin Adriamycin |
X | X | Protect from light and retain in carton until time of use.6,7,130 Stability of reconstituted solutions is affected by light exposure; refer to prescribing information and tertiary source for details regarding storage after reconstitution.6,130 | ||
| Doxycycline | X | X | X | X | Protect from light and retain in carton until time of use.6,7,131 Stability is affected by light exposure; refer to prescribing information for details regarding storage and light after reconstitution, dilution, and during administration.131 |
| Droperidol | X | Protect from light and retain in carton until time of use.6,7,132 | |||
| Ecallantide Kalbitor |
X | Protect vials from light until use.5,133 | |||
| Eculizumab Soliris |
X | Store in the original carton until time of use and protect from light.7,134 | |||
| Ephedrine | X | Protect from light.6,135 | |||
| Epinephrine Adrenalin EpiPen EpiPen Jr |
X | Adrenalin: Protect from exposure to light.6,7,136 EpiPen and EpiPen Jr: Protect from light.6,137 Store auto-injectors in the provided carrier tube.137 | |||
| Epirubicin Ellence |
X | X | Protect from light.7,138 Protect intact vials from exposure to light.6 Stability of reconstituted solutions is affected by light exposure; refer to tertiary source for details regarding storage after reconstitution. | ||
| Epoetin Alfa Epogen Procrit |
X | Protect from light and store in original containers until time of use.7,139,140 | |||
| Epoprostenol Flolan Veletri |
X | X | X | Flolan: Unopened vials should be protected from light in the carton.6,7,141 Prior to use, reconstituted solutions must be protected from light if not used immediately. Do not expose to direct sunlight during storage or in use. Veletri: Unopened vials should be protected from light in the carton.7,142 Prior to use, solutions reconstituted with 5 mL diluent must be protected from light.142 Do not expose solution to direct sunlight. | |
| Eptifibatide Integrilin |
X | Protect from light until administration.6,7,143 | |||
| Esomeprazole Nexium I.V. |
X | Protect from light and store in carton until time of use.6,7,144 | |||
| Etanercept Enbrel |
X | Keep the product in the original carton to protect from light until the time of use.5,145 | |||
| Ethanolamine Ethamolin |
X | Protect from light.5,146 | |||
| Etoposide Phosphate Etopophos |
X | Retain in original package to protect from light.6,147 | |||
| Exenatide Bydureon Byetta |
X | Bydureon: Protect from light until ready to prepare and use dose.5,148 Byetta: Protect from light.5,149 | |||
| Factor VIIa (Recombinant) NovoSeven RT |
X | X | Protect from light prior to reconstitution.150 Keep mixed solution out of direct light.5,150 | ||
| Factor XIII Concentrate (Human) Corifact |
X | Keep in original carton to protect from light.7,151 | |||
| Fentanyl Sublimaze |
X | Protect from light.6,7,152 | |||
| Fibrinogen Concentrate (Human) RiaSTAP |
X | Protect from light and keep in original carton until ready to use.7,153 | |||
| Fluorouracil Adrucil |
X | Protect from light and retain in carton until time of use.6,7,154 Exposure to sunlight or intense incandescent light has caused degradation.6 | |||
| Fluphenazine Decanoate | X | Protect from light and retain vial in carton until ready for use.5,155 | |||
| Fluphenazine Hydrochloride | X | Solutions should be protected from light.5,6,156 | |||
| Folic Acid | X | Protect from light and retain vial in carton until contents are used.6,7,157 | |||
| Follitropin Alfa Gonal-f Gonal-f RFF Gonal-f RFF Pen |
X | X | Protect from light.5,158–160 The single use vial and pen should be protected from light during storage.159,160 The multidose vial only requires protection from light after reconstitution.158 | ||
| Follitropin Beta Follistim Follistim AQ |
X | Protect from light.5,161,162 Keep container in carton.162 | |||
| Fulvestrant Faslodex |
X | Protect from light and store in the original carton until time of use.5,163 | |||
| Furosemide | X | Protect from light.6,7,164 Refer to tertiary source for details regarding specific mechanisms of photodegradation. | |||
| Gadodiamide Omniscan |
X | Protect from strong daylight and direct exposure to sunlight.165 | |||
| Gadofosveset Ablavar Vasovist |
X | Protect from light.5,166,167 | |||
| Gadopentetate Dimeglumine Magnevist |
X | Injection should be protected from light.5,168 | |||
| Gadoteridol ProHance |
X | Protect from light.169 | |||
| Gadoversetamide optiMARK |
X | Protect from light.5,170 | |||
| Galsulfase Naglazyme |
X | Protect from light.171 | |||
| Ganirelix | X | Protect from light.172 | |||
| Glatiramer Copaxone |
X | Protect from light when not injecting.173 Exposure to intense light should be avoided.5,173 | |||
| Glucagon (rDNA origin) GlucaGen Hypokit |
X | Keep in original package to protect from light.7,174 | |||
| Gold Sodium Thiomalate Myochrysine |
X | Protect from light and store in carton until contents have been used.5,175 | |||
| Golimumab Simponi |
X | Keep the product in the original carton until the time of use to protect from light.5,176 | |||
| Granisetron | X | Protect from light and retain in carton until time of use.6,7,177 | |||
| Haemophilus Influenza Type B Conjugate Vaccine Hiberix |
X | Vials should be protected from light.178 The manufacturers of PedvaxHIB and ActHIB provide no recommendations regarding light protection.179–180 | |||
| Haloperidol Decanoate Haldol Decanoate |
X | Protect from light and keep in carton until empty.5,181 | |||
| Haloperidol Lactate | X | Protect from light.6,182 | |||
| Human Papillomavirus Vaccine Gardasil |
X | Protect from light.183 The manufacturer of Cervarix provides no recommendation regarding light protection.184 | |||
| Hyaluronic Acid Derivatives Euflexxa Hyalgan Synvisc Synvisc-One |
X | Store in the original packaging and protect from light.3,5,185–188 The manufacturers of Supartz and Orthovisc provide no recommendations regarding light protection.189,190 | |||
| Hyaluronidase Vitrase |
X | Protect from light.5,191 | |||
| Hydrocortisone Sodium Succinate Solu-cortef |
X | Protect reconstituted solution from light.6,7,192 | |||
| Hydromorphone Dilaudid Dilaudid-HP |
X | X | Protect from light and keep covered in carton until time of use.6,7,193 Stability of diluted solutions is affected by light exposure; refer to prescribing information for details regarding storage after dilution.193 | ||
| Hydroxocobalamin | X | Protect from light.194 | |||
| Hydroxyprogesterone Makena |
X | Protect vial from light and store vial in original box.5,195 | |||
| Hydroxyzine | X | Protect from light.196 | |||
| Ibuprofen Lysine NeoProfen |
X | Protect from light and store vials in carton until contents have been used.6,7,197 | |||
| Idarubicin Idamycin PFS |
X | Protect from light and retain in carton until time of use.6,198 | |||
| Idursulfase Elaprase |
X | Protect from light.5,199 | |||
| Immune Globulin (Human) Flebogamma DIF Gammagard Liquid Gammaplex Hizentra Privigen |
X | Recommended storage conditions vary among immune globulin products.6,7 Check the individual prescribing information for the specific product for further information. In general, the listed brand products require light protection by storing in the original container.200–204 The manufacturers of other products provide no recommendations regarding light protection.205–209 | |||
| Indigotindisulfonate Indigo Carmine |
X | Store in the dark, away from direct light, preferably in the original package.5,210 | |||
| Indomethacin Indocin |
X | Protect from light and store in carton until contents have been used.6,7,211 | |||
| Influenza (Inactivated) Vaccine Afluria Fluarix Flublok Flucelvax FluLaval Fluvirin |
X | Protect from light.212–217 Store in the original package.213,216,217 | |||
| Insulin Aspart Insulin Aspart/Protamine Novolog Novolog 70/30 |
X | Keep unopened product in the carton to protect from light.218,219 Do not expose opened or unopened product to excessive/direct heat and sunlight.7,218,219 | |||
| Insulin Detemir Levemir |
X | Keep unopened product in the carton to protect from light.220 Do not expose opened or unopened product to direct heat or sunlight.5,220 | |||
| Insulin Glulisine Apidra Apidra Solostar |
X | Protect from light.221 Keep opened and unopened product away from direct heat and sunlight.7,221 | |||
| Insulin Glargine Lantus |
X | Keep opened and unopened product away from direct heat and light.5,222 | |||
| Insulin Lispro Insulin Lispro/Protamine Humalog Humalog Mix 50/50 Humalog Mix 75/25 |
X | Keep unopened product in its original carton to protect from light.223 Protect opened and unopened product from direct heat and light.5,6,223–225 | |||
| Insulin Isophane (NPH) Insulin Isophane (NPH)/Regular Novolin N Humulin N |
X | Novolin N: Keep unopened products in the carton to protect from light.226 Keep opened products away from direct heat and light. Humulin N: Keep opened products away from direct heat and light.227 | |||
| Insulin Regular Novolin R Humulin R |
X | Novolin R: Store unopened vials in original carton to protect from light.228 Keep opened vials away from heat and light. Humulin R: Keep opened vials away from heat and light.6,7,229 | |||
| Interferon Beta-1a Avonex Rebif |
X | Protect from light.5,230,231 | |||
| Iodipamide Meglumine Cholografin |
X | Protect from light.6,232 | |||
| Iodixanol Visipaque |
X | Protect polymer bottles from strong daylight and direct exposure to sunlight.6,233 Do not remove foil overwrap until immediately before use.6 | |||
| Iohexol Omnipaque |
X | Protect polymer bottles from strong daylight and direct exposure to sunlight.6,234 Protect solution from exposure to light.234 Do not remove containers from light-protective foil overwrap until immediately before use.6 | |||
| Iopamidol Isovue Isovue-M |
X | Protect from light.6,235,236 | |||
| Iopromide Ultravist |
X | Protect from light.5,237 | |||
| Iothalamate Meglumine Conray |
X | Protect from strong daylight or direct exposure to the sun.5,6,238 | |||
| Ioversol Optiray |
X | Protect from strong daylight or direct exposure to the sun.239 | |||
| Ioxaglate Meglumine and Ioxaglate Sodium Hexabrix |
X | Protect from strong daylight or direct exposure to the sun.5,6,240 | |||
| Ipilimumab Yervoy |
X | Protect vials from light.7,241 | |||
| Irinotecan Camptosar |
X | X | Protect from light and keep the vial in the carton until the time of use.6,7,242 Stability of diluted solutions is affected by light exposure; refer to prescribing information and tertiary sources for details regarding storage after dilution. | ||
| Isoniazid | X | Protect from light.243 | |||
| Isoproterenol Isuprel |
X | Protect from light and keep in opaque container until used.6,244 | |||
| Ixabepilone Ixempra |
X | Retain in original package until time of use to protect from light.7,245 | |||
| Japanese Encephalitis Virus Vaccine Ixiaro |
X | Store in the original package to protect from light.5,246 | |||
| Ketamine Ketalar |
X | Protect from light.6,247 May darken upon prolonged exposure to light, but this darkening does not affect concentration. | |||
| Ketorolac Tromethamine | X | Protect from light and retain in carton until time of use.6,7,248 Prolonged exposure to light may result in discoloration of the solution and precipitation. | |||
| Labetalol | X | Protect from light.6,7,249 | |||
| Lanreotide Somatuline Depot |
X | Protect from light in its original package and keep pouch sealed until injection.5,250 | |||
| Laronidase Aldurazyme |
X | Protect from light.251 | |||
| Leucovorin | X | Protect from light and retain in carton until time of use.5,6,252 | |||
| Leuprolide | X | Protect from light and store vial in carton until contents are used.5,253 | |||
| Levocarnitine | X | All generic manufacturers recommend to store in carton until time of use to protect from light.254–256 The manufacturer of Carnitor provides no recommendation regarding light protection.257 | |||
| Levofloxacin Levaquin |
X | Vials and pre-mixed solutions should be protected from light.6,7,258 | |||
| Levoleucovorin Fusilev |
X | Store vials of both lyophilized powder and ready-to-use solution in carton until contents are used.7,259 | |||
| Levothyroxine | X | Protect from light.6,260 | |||
| Lidocaine Lidocaine /Epinephrine Xylocaine MPF |
X | Vials and premixed solutions should be protected from light.6,261 | |||
| Liraglutide Victoza |
X | Protect from excessive sunlight.5,262 | |||
| Linezolid Zyvox |
X | Protect from light.6,7,263 Infusion bags should be kept in the overwrap until ready to use.5,6,7,263 | |||
| Lorazepam Ativan |
X | Use carton to protect contents from light.6,7,264 | |||
| Measles, Mumps, and Rubella Virus Vaccine M-M-R II |
X | X | Protect the vaccine from light at all times, since such exposure may inactivate the viruses.5,265 Stability of reconstituted vaccine is affected by light exposure; refer to prescribing information for details regarding storage after reconstitution.265 | ||
| Measles, Mumps, Rubella, and Varicella Virus Vaccine ProQuad |
X | X | Protect the vaccine from light at all times since such exposure may inactivate the vaccine viruses.5,266 If not used immediately, reconstituted vaccine may be stored for up to 30 minutes if protected from light. | ||
| Mecasermin Increlex |
X | Protect unopened and opened vials from direct light.5,267 | |||
| Mechlorethamine Mustargen |
X | Protect from light.5,268 | |||
| Melphalan Alkeran |
X | Protect from light.6,7,269 | |||
| Meningococcal Conjugate Vaccine Menveo |
X | Protect from light.270 The manufacturer of Menactra provides no recommendation regarding light protection.271 | |||
| Menotropins Repronex |
X | Protect from light.5,272 | |||
| Mepivacaine and Mepivacaine/ Levonordefrin Scandonest Plain, Scandonest L |
X | For protection from light, retain in box until time of use.273 Once opened, the box should be reclosed. | |||
| Methadone | X | Protect from light and store in carton until contents have been used.6,7,274 | |||
| Methotrexate | X | X | Protect from light.6,7,275 Stability of diluted solutions is affected by light exposure; refer to tertiary source for details regarding storage after dilution. | ||
| Methylergonovine Methergine |
X | Protect from light.6,7,276 | |||
| Methylnaltrexone Relistor |
X | Protect from light.5,277 Refer to prescribing information for details regarding storage and light after the solution is drawn into syringe.277 | |||
| Methylprednisolone Sodium Succinate A-Methapred |
X | Protect from light.6,7,278 | |||
| Metoclopramide Reglan |
X | X | Protect from light and store vials in carton until used.6,7,279 Stability of diluted solutions is affected by light exposure; refer to prescribing information for details regarding storage after dilution.279 | ||
| Metoprolol Tartrate Lopressor |
X | Protect from light.6,7,280 | |||
| Metronidazole Flagyl |
X | Protect from light during storage.6,7,281 Refer to tertiary source for details regarding light effects. | |||
| Micafungin Mycamine |
X | X | X | Vials are coated with a light protective fi lm.282 The diluted solution should be protected from light.6,7,282 It is not necessary to cover the infusion drip chamber or the tubing.282 | |
| Mipomersen Kynamro |
X | Protect from light and keep in the original carton until time of use.5,283 | |||
| Mitomycin | X | X | Intact vials and reconstituted solutions should be protected from light.5,6,284 | ||
| Morphine Astramorph PF Duramorph |
X | Protect from light and store in carton until ready to use.6,7,285,286 | |||
| Nalbuphine | X | Protect from light and store in carton until contents have been used.6,7,287 | |||
| Naloxone | X | Protect from light.6,7,288 | |||
| Natalizumab Tysabri |
X | Protect from light.7,289 | |||
| Neostigmine | X | Protect from light and store in shelf pack until time of use.6,7,290 Refer to tertiary source for details regarding storage and light after the solution is drawn into syringe.6 | |||
| Nesiritide Natrecor |
X | Keep the vial in the outer carton in order to protect from light.6,291 | |||
| Nicardipine Cardene I.V. |
X | X* | Store in carton protected from light.6,7,292 *Stability of diluted solutions is affected by exposure to daylight; one tertiary source states that protection from light may be considered for diluted solutions.6 |
||
| Nitroglycerin | X | Protect vials from light and retain vials in carton until time of use.5,7,293,294 Diluted solutions do not require protection from light.6,295 | |||
| Nitroprusside Nitropress |
X | X | X | X | Store vials in carton in order to protect from light.5,296 Stability is affected by light exposure; refer to prescribing information and tertiary source for details regarding storage and light after reconstitution, dilution, and during administration.7,296 |
| Norepinephrine Levophed |
X | Protect from light.6,7,297 | |||
| Ocriplasmin Jetrea |
X | Protect the vials from light by storing in the original package until time of use.5,298 | |||
| Octreotide Sandostatin |
X | Store in outer carton to protect from light.6,7,299 | |||
| Ofatumumab Arzerra |
X | Vials should be protected from light.7,300 | |||
| Olanzapine Zyprexa |
X | Protect from light.5,301 | |||
| Omalizumab Xolair |
X | Reconstituted vials should be protected from direct sunlight.302 | |||
| Omacetaxine Synribo |
X | X | Until use, keep product in carton to protect from light.5,303 Protect reconstituted solution from light.303 | ||
| Ondansetron Zofran |
X | Protect vials from light.6,7,304 | |||
| Oprelvekin Neumega |
X | X | Lyophilized powder and diluents should be protected from light.5,305 | ||
| Orphenadrine | X | All generic manufacturers recommend to protect from light.306–309 One generic manufacturer states to retain in carton until time of use.309 The manufacturer of Norflex provides no recommendation regarding light protection.310 | |||
| Oxaliplatin Eloxatin |
X | Vials with concentrate for solution should be protected from light by keeping in the outer carton.6,7,311 Store unopened vials containing powder for solution under normal lighting conditions. | |||
| Oxymorphone Opana |
X | Protect from light.7,312 | |||
| Paclitaxel Abraxane |
X | Protect intact vials from light.6,7,313 Retain in the original package to protect from bright light.314 | |||
| Palifermin Kepivance |
X | X | Protect from light and keep vials in carton until time of use.7,315 Stability of reconstituted solutions is affected by light exposure; refer to prescribing information for details regarding storage after reconstitution.315 | ||
| Palonosetron Aloxi |
X | Protect from light.6,7,316 | |||
| Panitumumab Vectibix |
X | Protect from direct sunlight and store vials in original carton until time of use.7,317 | |||
| Pantoprazole Sodium Protonix I.V. |
X | Protect from light.6,7,318 | |||
| Papaverine | X | Protect from light and retain in carton until time of use.6,319 | |||
| Pasireotide Signifor |
X | Protect from light and store in original carton.5,320 | |||
| Pegfilgrastim Neulasta |
X | Store in the carton to protect from light.5,321 | |||
| Peginesatide Omontys |
X | Protect from light and store in carton until time of use.322 | |||
| Peginterferon Alfa-2a Pegasys |
X | Protect from light.5,323 | |||
| Pegloticase Krystexxa |
X | X | Protect from light and store in the carton.5,7,324 Stability of diluted solutions is affected by light exposure; refer to prescribing information for details regarding storage after dilution.324 | ||
| Pentamidine Pentam 300 |
X | X | Protect dry product and reconstituted solution from light.6,7,325 Stability of reconstituted solutions is affected by light exposure; refer to prescribing information for details regarding storage after reconstitution.325 | ||
| Pertuzumab Perjeta |
X | Keep vial in the outer carton in order to protect from light.5,326 | |||
| Phenylephrine | X | Protect from light and keep covered in carton until time of use.6,7,327 | |||
| Phytonadione Vitamin K1 |
X | X | X | Protect from light at all times.6,328 One source states to protect from light before use and during all dilutions.7 Keep ampuls in tray until time of use.328 Refer to tertiary source for details regarding photostability.6 | |
| Poliovirus Vaccine (Inactivated) IPOL |
X | Protect from light.329 | |||
| Polymyxin B | X | Protect from light and retain in carton until time of use.6,330 | |||
| Porfimer Photofrin |
X | X | Store unopened vials in carton to protect from light.7 The reconstituted product should be protected from bright light and used immediately.331 | ||
| Pralatrexate Folotyn |
X | Store in original carton to protect from light.7,332 | |||
| Pramlintide Symlin |
X | Protect unopened vials and pen-injectors from light.5,333 | |||
| Prilocaine and Epinephrine Citanest Forte |
X | Solutions containing epinephrine should be protected from light.334 | |||
| Procaine Novocain |
X | Protect solutions from light.335 | |||
| Prochlorperazine | X | Protect from light and store in the box until ready to use.7,336 Solutions should be protected from light.6,336 Refer to tertiary source for details regarding light and stability.6 | |||
| Promethazine Phenergan |
X | Protect from light and keep covered in carton until time of use.6,7,337 | |||
| Propranolol | X | Protect from light and retain in carton until time of use.5,6,338 | |||
| Protein C Concentrate (Human) Ceprotin |
X | Store the vial in the original carton to protect it from light.7,339 | |||
| Pyridostigmine Regonol |
X | Protect from light.340 | |||
| Pyridoxine | X | Protect from light.6,7,341 | |||
| Rabies Vaccine RabAvert |
X | Lyophilized powder should be protected from light.342 The manufacturer of Imovax Rabies provides no recommendation regarding light protection.343 | |||
| Ranibizumab Intravitreal Lucentis |
X | Protect vial from direct sunlight and store in the original carton until time of use.344 | |||
| Ranitidine Zantac |
X | Protect from light and store vial in carton until time of use.6,7,345 | |||
| Rasburicase Elitek |
X | Protect from light.7,346 | |||
| Raxibacumab | X | Keep vials in their cartons to protect from light prior to use.347 | |||
| Reteplase Retavase |
X | The box should remain sealed until use to protect from exposure to light.6,7,348 | |||
| Rho(D) Immune Globulin Intravenous Rhophylac |
X | Keep in the original carton to protect from light.7,349 | |||
| Rifampin Rifadin |
X | Protect from light.6,7,350 | |||
| Rilonacept Arcalyst |
X | X | Store inside the original carton to protect from light.5,351 Stability of reconstituted solutions is affected by light exposure; refer to prescribing information for details regarding storage after reconstitution.351 | ||
| Rimabotulinumtoxin B Myobloc |
X | Protect from light.352 | |||
| Risperidone Risperdal Consta |
X | The entire dose pack should be protected from light.5,353 | |||
| Rituximab Rituxan |
X | Vials should be protected from direct sunlight.354 Protect from light.7 | |||
| Romiplostim Nplate |
X | X | Store vials in their carton to protect from light until time of use.5,355 Protect the reconstituted product from light. | ||
| Scopolamine | X | Protect from light.6,356 Opaque covering needed until contents used.356 | |||
| Secretin Human ChiRhoStim |
X | Protect from light.5,357 | |||
| Sodium Nitrite | X | Protect from direct light.358 | |||
| Somatropin Genotropin Norditropin Nutropin AQ Omnitrope Tev-Tropin |
X |
Genotropin, Tev-Tropin: Protect from light.359,360 Norditropin: Avoid direct light.361 Nutropin AQ: Store refrigerated in a dark place when not in use.362 Omnitrope: The product is light sensitive and should be stored in the carton.363 The manufacturers of other products provide no recommendations regarding light protection.364–368 |
|||
| Streptomycin | X | X | Protect from light.6,369 Sterile reconstituted solutions should be protected from light.369 | ||
| Streptozocin Zanosar |
X | Unopened vials should be protected from light and preferably stored in carton.6,7,370 | |||
| Sufentanil Sufenta |
X | Protect from light.6,371 | |||
| Sumatriptan Imitrex Alsuma |
X | Protect from light.6,372,373 | |||
| Taliglucerase Alfa Elelyso |
X | X | X | Protect from light.5,374 Stability of reconstituted and diluted solutions is affected by light exposure; refer to prescribing information for details regarding storage after reconstitution and dilution.374 | |
| Temsirolimus Torisel |
X | X | X | Protect from light.7,375 Protect from excessive room light and sunlight during handling and preparation. | |
| Teniposide Vumon |
X | Retain in original package to protect from light.6,376 | |||
| Terbutaline | X | Protect from light.6,377 Refer to tertiary source for details regarding storage and light after the solution is drawn into syringe.6 | |||
| Teriparatide Forteo |
X | Recap the delivery device when not in use to protect the cartridge from physical damage and light.5,378 | |||
| Tesamorelin Egrifta |
X | Vials should be protected from light and be kept in the original box until time of use.379 | |||
| Testosterone Depo-Testosterone |
X | Protect from light.380 | |||
| Tetracaine | X | Protect ampules and vials from light.6,381 | |||
| Thiamine | X | Protect from light.6,7,382 Refer to tertiary source for details regarding storage and light after the solution is drawn into syringe. | |||
| Thiotepa | X | X | X | X | Protect from light at all times.7,383 Reconstituted solutions should be protected from light until used.6 |
| Thyrotropin Alfa Thyrogen |
X | Protect from light.5,384 | |||
| Tirofiban Aggrastat |
X | Protect from light during storage.6,7,385 | |||
| Tocilizumab Actemra |
X | X | Protect the vials from light by storage in the original package until time of use.7,386 Stability of diluted solutions is affected by light exposure; refer to prescribing information for details regarding storage after dilution.386 | ||
| Topotecan Hycamtin |
X | X | Store the vials protected from light in the original package.6,7,387 Stability of reconstituted solutions is affected by light exposure; refer to tertiary source for details regarding storage after reconstitution.6 | ||
| Tositumomab Bexxar |
X | Protect from strong light.7,388 Instructions for I-131 tositumomab do not specify to protect from light.388 | |||
| Triamcinolone Acetonide Kenalog-10 |
X | Protect from light.389 | |||
| Triamcinolone Acetonide Intravitreal Triesence |
X | Protect from light by storing in carton.5,390 | |||
| Triamcinolone Hexacetonide Intra-Articular/Intralesional Aristospan |
X | Protect from light.391 | |||
| Tuberculin Skin Test Aplisol |
X | Protect from light.5,392 | |||
| Urofollitropin Bravelle |
X | Protect from light.5,393 | |||
| Ustekinumab Stelara |
X | Keep the product in the original carton to protect from light until the time of use.5,394 | |||
| Varicella Virus Vaccine Live Varivax |
X | Protect from light before reconstitution.5,395 | |||
| Vecuronium | X | Protect from light and retain in carton until time of use.6,396 | |||
| Velaglucerase Alfa Vpriv |
X | Protect vial from light.5,397 | |||
| Verapamil | X | X | Protect from light by retaining in package until ready to use.6,7,398 Stability of diluted solutions is affected by light exposure; refer to prescribing information for details regarding storage after dilution.398 | ||
| Verteporfin Visudyne |
X | X | Reconstituted product must be protected from light and used within 4 hours.5,7,399 After dilution, protect from light and use within a maximum of 4 hours.399 | ||
| Vinblastine | X | X | Protect from light and retain vial in carton until time of use.400 Although protection from light is not recommended by the manufacturer of the powder form, one tertiary source and another manufacturer’s prescribing information states that both powder and solution forms should be protected.6,401 | ||
| Vincristine Vincasar PFS |
X | Protect from light and retain in carton until time of use.6,402 The manufacturer of Marqibo provides no recommendation regarding light protection.403 | |||
| Vinorelbine Navelbine |
X | Protect from light by storing in the carton.6,7,404 | |||
| Vitamin A Aquasol A |
X | X | Protect from light.6,405 Stability of vitamin A in parenteral nutrition solutions is affected by light exposure; refer to tertiary source for details regarding storage after dilution in parenteral nutrition solutions. | ||
| Von Willebrand Factor/ Coagulation Factor VIII Complex Wilate |
X | Store in the original container to protect from light.7,406 | |||
| Warfarin Coumadin |
X | Protect from light and keep vial in box until used.6,7,407 | |||
| Ziconotide Prialt |
X | Protect from light.6,408 | |||
| Zidovudine Retrovir |
X | Protect from light.6,7,409 | |||
| Ziprasidone Geodon |
X | X | Protect from light.5,410 Stability of reconstituted solutions is affected by light exposure; refer to prescribing information for details regarding storage after reconstitution.410 | ||
| ZIV-Aflibercept Zaltrap |
X | Keep the vials in the original outer carton to protect from light.5,411 | |||
| Zoster Vaccine, Live, Attenuated Zostavax |
X | Protect from light prior to reconstitution.5,412 | |||
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