Table 1. Contraindications, warnings, and precautions for dolutegravir and raltegravir^1,2.

	Dolutegravir	Raltegravir
Contraindications
Coadministration with dofetilide	X
Warnings and precautions
Hypersensitivity reactions	X	X
Hepatitis coinfection	X
Fat redistribution	X
Immune reconstitution syndrome	X	X
Phenylketonurics		X
Special populations
Renal impairment	Caution in INSTI-experienced patients with severe renal impairment	No unique precautions
Hepatic impairment	Not recommended in severe impairment	Not studied in severe impairment
Pediatric patients	12 years and older and weighing ≥40 kg	2 to 18 years of age
Elderly patients	Caution	Caution
Pregnancy	Category B	Category C
Antiretroviral pregnancy registry	Recommended
Breast-feeding	Avoid	Avoid

Note: INSTI = integrase strand transfer inhibitor.