Table 2. SNPs in significant association with grade 3 and 4 hematological toxicity in S0221 trial.

Gene	SNP	Genotype	# Grade 3/4 vs. grade ≤2	Adjusted OR (95% CI)*	Praw	Ppermutation
ABCC1	rs903880	CC	148/355	1.00	0.006	0.23
		CA	108/191	1.38 (1.02-1.88)
		AA	34/46	1.86 (1.10-3.15)
		AA+AC	142/237	1.46 (1.09-1.95)	0.01	0.39
ABCC1	rs16967126	AA	229/507	1.00	0.03	0.65
		AG	59/79	1.63 (1.12-2.37)
		GG	2/6	0.63 (0.12-3.22)
		AG/GG	61/85	1.55 (1.08-2.25)	0.02	0.52
ABCC1	rs4148350	CC	244/527	1.00	0.12	0.72
		CA	46/64	1.54 (1.02-2.33)
		AA	0/1	-
		CA/AA	46/65	1.52 (1.01-2.29)	0.05	0.61
ALDH1A1	rs8187996	GG	253/543	1.00	0.10	0.65
		GA	36/48	1.63 (1.02-2.58)
		AA	1/1	2.05 (0.13-33.87)
		GA/AA	49/37	1.64 (1.04-2.58)	0.04	0.61
ALDH1A1	rs3764435	CC	63/160	1.00	0.004	0.21
		AC	127/286	1.11 (0.77-1.56)
		AA	100/145	1.76 (1.18-2.61)
		AC+AA	227/431	1.64 (1.20-2.25)	0.002	0.16
ALDH1A1	rs63319	CC	71/176	1.00	0.05	0.65
		CA	135/277	1.19 (0.84-1.68)
		AA	84/139	1.48 (1.00-2.18)
		CA+AA	219/416	1.28 (0.93-1.77)	0.13	0.78

Footnote:

^*Logistic regression model adjusted for age of diagnosis, treatment arm and genetic ancestry.