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. 2014 Mar 3;9(3):e90013. doi: 10.1371/journal.pone.0090013

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© 2014 Calil et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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HePas and Hej mice received i.pl. injection of saline (20 µl), TNF-α (100 pg/paw), CXCL1 (20 ng/paw), IL-1β (1 ng/paw), PGE₂ (100 ng/paw) or dopamine (10 µg/paw). Mechanical hyperalgesia was evaluated 3 h after i.pl. injection of hyperalgesic mediators. *P<0.05 compared with saline control. One-way ANOVA followed by Tukey's t test.