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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: J Pathol. 2013 Mar 14;230(1):82–94. doi: 10.1002/path.4171

Figure 4. miR-26a inhibits NO production and decreases the viability, adhesion, and migration of NPM-ALK+ T-cell lymphoma.

Figure 4

Figure 4

(A) miR-26a decreased NO production by Karpas 299 and DEL cells (*: p < 0.01 vs. control; RFU = Relative Fluorescence Units); (B) miR-26a decreased viability and this effect was diminished by the NO donor SNAP (*: p < 0.0001 vs. control and p < 0.001 vs. miR-26a+SNAP, †: p < 0.00001 vs. control and miR-26a+SNAP); (C) miR-26a decreased adhesion of lymphoma cell lines to endothelial cells and SNAP effectively reversed the effects of miR-26a (*: p < 0.00001 vs. control and p < 0.01 vs. miR-26a+SNAP, †: p < 0.000001 vs. control and miR-26a+SNAP); (D) miR-26a abrogated the stimulatory effects of IGF-I on migration of Karpas 299 and DEL cells, and this effect was inhibited by SNAP (*: p < 0.01 vs. untreated cells and IGF-I+miR-26a; †: p < 0.01 vs. untreated cells and p < 0.05 vs. IGF-I+miR-26a). cel-miR-67 was used as the negative control miR. Results represent 3 independent experiments and are shown as means ± SE.