Figure 2. Concentrations of the nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA) in mouse lung homogenates of untreated (naïve) control as well as Pseudomonas infected mice treated with PBS or the arginase inhibitor 2(S)-amino-6-boronohexanoic acid (ABH).

ADMA was significantly lower in naïve compared to Pseudomonas infected lungs (*: p = 0.0001, Kruskal-Wallis test). The L-arginine/ADMA ratio, which can be used as an index of NOS impairment, was significantly reduced in infected lungs (*: p<0.0001, ANOVA). Treatment with ABH did not change ADMA concentrations but resulted in normalization of the L-arginine/ADMA ratio. (p<0.001, t-test).