Table 1. Concentrations (µmol/L) of the L-ornithine derived polyamines putrescine, spermidine and spermine in lung homogenates of naïve control and Pseudomonas infected mice treated with PBS or arginase inhibitor ABH.
Putrescine | Spermidine | Spermine | |
Control | 4.9±1.2 * | 4.0±1.2 * | 2.6±0.7 * |
Pseudomonas | |||
PBS | 34.2±2.4 | 39.6±2.3 | 13.6±0.8 |
ABH | 28.7±2.9 | 37.5±3.7 | 12.5±0.8 |
* Concentrations were significantly different between groups (p<0.001, ANOVA). All three polyamines were lower in controls compared to infected animals but not different between PBS or ABH treatment group (n = 6–8/group).