Table 2. Cytokine concentrations (ng/g) in lung homogenates of naïve control and Pseudomonas infected mice treated with PBS or arginase inhibitor ABH.
P. aeruginosa | |||
Control (n = 6) | PBS (n = 14) | ABH (n = 15) | |
IFN-γ | 0.04±0.01 * | 3.50±0.83 | 2.54±0.52 |
IL-1β | 8.54±0.96 | 15.51±3.02 | 12.26±2.37 |
IL-6 | 9.97±0.51 * | 52.27±5.67 | 65.09±12.1 |
MIP-2 | 0.15±0.01 * | 59.46±7.30 | 44.29±3.67 |
KC | 4.52±1.43 * | 31.84±5.90 | 29.28±3.58 |
TNF-α | 0.05±0.01 * | 7.61±1.41 | 5.48±0.83 |
Concentrations were significantly different between groups (p<0.001, Kruskal-Wallis test). All cytokines with the exception of IL-1β were lower in controls compared to infected animals not different between PBS and ABH treated animals.