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MRCK signalling pathway. The MRCK kinases phosphorylate substrates that may either be activating (green arrow) or inactivating (red arrow). Phosphorylation of MYPT1 reduces MLC dephosphorylation (red arrow), while LIM kinase (LIMK) phosphorylation of Cofilin blocks its filamentous actin severing activity (red arrow). Two consecutive red arrows results in inhibition of a negative activity. The net effect of these events is increased actin-myosin contraction
