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. 2013 Dec 9;2(12):e81. doi: 10.1038/oncsis.2013.43

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Copyright © 2013 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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MMTV-PTK6 transgenic animals develop neoplastic hyperplasia and mammary gland tumors. Transgenic animals developed mammary gland lesions and mammary gland tumors at older age. Whole mount staining was performed on the thoracic mammary glands (a–c) of transgenic animals. Age and parous status were noted in the figure. Hyperplastic alveolar nodules (HAN) (black arrow) were observed in animals as early as 70 weeks of age, and were frequently detected in the aging animals (a–c). Multiple mammary gland tumors (red arrow) were found in the animal of 105 weeks (d). Immunohistochemistry performed on corresponding mammary glands confirmed PTK6 transgene expression (e–h).