Table 1. mtDNA point mutations, mtDNA large deletions and BRCA2 protein levels in prostate carcinoma specimens.
Point mutations |
|||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Sample | Base change | Amino-acid change | Gene | Het | PSIC | Somatic | Variability | ID | Large deletions (n) | mtDNA content (%) | BRCA2 protein (%) |
BPH 1 | A15929G | — | MT-TT | − | n.a. | 0.002 | PA_XX_XX_183 | 0 | 83 | 45 | |
BPH 2 | T12713C | I126T | MT-ND5 | − | 0.003 | n.a. | 0.000 | PA_XX_XX_188 | 2 | 98 | 61 |
BPH 3 | G9300A | A32T | MT-COIII | − | 0.000 | n.a. | 0.019 | PA_XX_XX_184 | 0 | 100 | 62 |
BPH 4 | T14501C | I58T | MT-ND6 | − | 0.514 | n.a. | 0.000 | PA_XX_XX_185 | 0 | 98 | 89 |
BPH 5 | A12634G | I100V | MT-ND5 | − | 0.925 | n.a. | 0.010 | PA_XX_XX_186 | 1 | 100 | 84 |
A13630G | T432A | MT-ND5 | − | 0.527 | n.a. | 0.006 | |||||
T8668C | W48R | MT-ATP6 | − | 0.999 | n.a. | 0.004 | |||||
BPH 6 | T5160C | S231P | MT-ND2 | − | 0.986 | n.a. | 0.000 | PA_XX_XX_187 | 2 | 91 | 100 |
PCa 1 | None | PA_XX_XX_168 | 7 | 34 | 5 | ||||||
PCa 2 | T11204C | F149L | MTND4 | − | 0.000 | Y | 0.020 | PA_XX_XX_169 | 6 | 98 | 5 |
PCa 3 | None | PA_XX_XX_170 | 5 | 56 | 13 | ||||||
PCa 4 | None | PA_XX_XX_171 | 5 | 89 | 11 | ||||||
PCa 5 | C9739T | A178V | MTCOIII | − | 0.018 | N | 0.000 | PA_XX_XX_172 | 5 | 76 | 16 |
PCa 6 | T11253C | I165T | MTND4 | − | 0.001 | N | 0.021 | PA_XX_XX_173 | 6 | 98 | 16 |
PCa 7 | G15428A | D228N | MTCYTB | + | 0.999 | Y | 0.000 | PA_XX_XX_174 | 13 | 100 | 8 |
T12631G | S99A | MTND5 | − | 0.003 | N | 0.001 | |||||
PCa 8 | None | PA_XX_XX_175 | 9 | 39 | 0.5 | ||||||
PCa 9 | None | PA_XX_XX_176 | 10 | 79 | 0.5 | ||||||
PCa 10 | None | PA_XX_XX_177 | 11 | 82 | 0.5 | ||||||
PCa 11 | None | PA_XX_XX_178 | 13 | 60 | 0.5 | ||||||
PCa 12 | G9738A | A178T | MTCOIII | − | 0.219 | N | 0.007 | PA_XX_XX_179 | 14 | 65 | 0.5 |
PCa 13 | None | PA_XX_XX_180 | 7 | 81 | 7 | ||||||
PCa 14 | A14220C | L152P | MTND6 | − | 0.999 | N | 0.000 | PA_XX_XX_181 | 9 | 80 | 10 |
G5849A | — | MT-TY | + | N | 0.000 | ||||||
PCa 15 | None | PA_XX_XX_182 | 16 | 31 | 0.25 |
Abbreviations: BPH, benign prostate hyperplasia; Het, heteroplasmy; n.a., information not available; PCa, prostate carcinoma.