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. 2013 Dec 23;2(12):e83. doi: 10.1038/oncsis.2013.46

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Copyright © 2013 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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(a) Quantative PCR assessment of chromosomal copy number for 11 cancer-related genes conducted on genomic DNA from KPL-4 parental and KPL-4PR cells. Copy number was calculated by normalizing to the RNAaseP gene, as described in the text. (b) FISH assay showing PIK3CA copy number in KPL-4 parental and two resistant clones. Chromosomal copies of PIK3CA are shown in red, and copies of the centromeric control gene CEP3 are shown in green. KPL-4PR.5 and KPL-4PR.18 clones show high-level amplification of the PIK3CA locus present in homogeneously staining regions, indicated by arrows.