Table 4. Mutation frequencies to resistance for linezolid and phage in S. aureus 43300 (MRSA).
Phage (MR-5) MOI-1* | Phage (MR-5) MOI-10** | Linezolid at (8 µg/ml) | Phage + linezolid (MOI-1+8 µg/ml) | Phage + linezolid (MOI-10+8 µg/ml) |
(7.5±1.1) ×10−6 | (1±0.31) ×10−7 | (5±1.2) ×10−9 | <10−9 | <10−9 |
MOI-1*: phage added at a multiplicity of 1 i.e 109 PFU of phage added.
MOI-10**: phage added at a multiplicity of 10 i.e 1010 PFU of phage added.