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. 2014 Mar 3;9(3):e90506. doi: 10.1371/journal.pone.0090506

Figure 1. C57BL substrain differences in myoclonic jerk thresholds.

Figure 1

The latency to the first myoclonic jerk (myoclonic jerk threshold (MJT)) on each seizure trial was determined for 5 C57BL substrains (n = 12 mice/substrain: 10SNJ, 10J, 6J, 6NJ, and KSJ) by exposure to 10% flurothyl during eight induction trials followed by a 28-day rest period and a single flurothyl retest. 10SNJ and 6J mice have the highest baseline MJT that are statistically indistinguishable. However, 6NJ and KSJ mice have significantly lower initial MJT as compared to all other substrains (P<0.0001). Additionally, four of the five individual substrains (6J, 10SNJ, 10J, 6NJ) showed significant differences in MJT across the 8 seizure trials (P<0.0001), except KSJ (P = 0.09). 1significantly different from 10SNJ, 10J, and 6J (P<0.02); 2significantly different from 10SNJ and 10J (P<0.04); 4significantly different from all other substrains (P≤0.05); 6significantly different from 10SNJ and KSJ (P<0.02); 7significantly different from 6J, 6NJ, and KSJ (P<0.01); 8significantly different from 10SNJ, 10J, and KSJ (P<0.02); 9significantly different from all substrains except 6J (P<0.03); 10significantly different from 6J and KSJ (P<0.04); 11significantly different from 10SNJ, 10J, and 6NJ (P<0.03).