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. 2014 Mar 4;5:177. doi: 10.3389/fpsyg.2014.00177

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Copyright © 2014 Pendergast, Branecky, Huang, Niswender and Yamazaki.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Acute effect of wheel-running activity on body weight and food intake. Male heterozygous PER2::LUC mice were single-housed at 7 weeks old in cages with either locked or freely rotating running wheels and provided with chow ad libitum for 1 week. At 8 weeks old, mice were provided with fresh chow (gray) or high-fat diet (HFD; black) for 1 week. The mean (±SD) weight gain (A; grams) and food intake (B; kcal metabolizable energy) were determined during 1 week of chow or HFD feeding. There was a main effect of diet [F_{(1, 32)} = 14.93, p < 0.001] and a significant interaction between wheel and diet [F_{(1, 32)} = 4.39, p = 0.04] on body weight gain. Mice with locked wheels consuming HFD gained more weight than chow-fed mice (^*p < 0.001). There were significant main effects of wheel [F_{(1, 32)} = 27.15, p < 0.001] and diet [F_{(1, 32)} = 8.28, p < 0.01] on food intake. Locked/chow n = 7; Locked/HFD n = 12; Free/chow n = 6; Free/HFD n = 11.