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(a) Domain composition of full-length CMTr1. The dashed lines indicate the region of the protein (CMTr1126–550) present in the crystal structure. The domain boundaries are indicated with residue numbers. (b) Crystal structure of CMTr1126–550 in complex with capped oligoribonucleotide (m7GpppGAUC; coloured yellow) and SAM (green). Helices are shown in orange, β-strands are shown in blue and loops are shown in white.
