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. 2014 Jan 9;5:3004. doi: 10.1038/ncomms4004

Figure 2. Homology model of CMTr21–423.

Figure 2

(a) Domain composition of CMTr2. The dashed lines indicate a part of the protein that was modelled based on the CMTr1126–550 crystal structure. The domain boundaries are indicated with residue numbers. (b) Homology model of the catalytic domain of CMTr2 in complex with capped oligoribonucleotide (m7GpppGGAA) and SAM. m7GpppGGAA and SAM are coloured yellow and green, respectively. Helices are shown in orange, β-strands are shown in blue and loops are shown in white. Residues that were studied in directed mutagenesis experiments are shown in gray spheres.