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. 2014 Jan 6;5:2958. doi: 10.1038/ncomms3958

Figure 2. Representative structure of the TRX and TXNIP complex and structural comparison between TXNIP and arrestin.

Figure 2

(a) TRX interacts exclusively with C-TXNIP in the complex structure. The β-strands and disordered regions of TXNIP are shown in cyan and as grey dashed lines, respectively. The cysteines in TXNIP are displayed as white carbon atoms. Cys63 is located 39 Å from Cys247 and 14.1 Å from Cys120. (b) TRX-bound TXNIP (cyan) superimposed onto mVPS26B (magenta) based on the C-terminal domains. The disordered regions of TXNIP and mVPS26B are shown as dashed cyan and magenta lines, respectively. (c) Superimposition of N-TXNIP and C-TXNIP (cyan) onto N-mVPS26B and C-mVPS26B (magenta). The disordered region of C-TXNIP is shown as a dashed white line. (d) The electrostatic surface potential of TXNIP shows a highly basic C-terminal domain and a relatively negative electrostatic N-terminal domain.